Friday, August 26, 2016

Is Sjogren's triggered by autoimmune cross-targeting? So many suspects..can we divide up sjogren's into several types?

Autoimmune cross-targeting hypothesis:  the layering of 2 different infections on one target triggers autoimmune disease.

A viral infection marking the inside of the target then an external infection marking the outside. One of each is needed to trigger autoimmunity.

Sjogren's: autoimmune disease of the salivary glands (target tissue)

external infection suspects that could be marking the outside of the gland:

mycoplasmas with RA associations
fungal with hoshimoto's thyroid
spirochetes with lichen sclerosis

viral internal infection suspects:

EBV/HHV8 (using alpha estrogen receptors)
retroviruses (using thrombopoietin receptors..RANK?)
hepatitis C (using mc1 receptors)
??? HPV16 (using CB1 receptors)????

mycoplasmas and sjogren's
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC477189/

RA and  sjogren's
http://www.medscape.com/viewarticle/808825
http://www.ncbi.nlm.nih.gov/pubmed/2200936

personal post sjogren's and lyme
http://sjogrensvegan.blogspot.com/

estrogen alpha receptor is involved with salivary cancer
http://www.ncbi.nlm.nih.gov/pubmed/19559968

(i think the EBV uses the alpha estrogen receptors)

EBV and sjogren's
http://www.ncbi.nlm.nih.gov/pubmed/1848394
http://www.ncbi.nlm.nih.gov/pubmed/1664987
http://www.ncbi.nlm.nih.gov/pubmed/1319486
http://www.ncbi.nlm.nih.gov/pubmed/3021847

HHV8 and sjogren's
http://www.ncbi.nlm.nih.gov/pubmed/9003115

HHV8 binds the alpha estrogen receptor
http://d-scholarship.pitt.edu/13517/

retrovirus and sjogren's subgroup
http://www.ncbi.nlm.nih.gov/pubmed/9155673
http://www.ncbi.nlm.nih.gov/pubmed/8531355
http://www.ncbi.nlm.nih.gov/pubmed/1628425

Rank receptor and sjogren's
http://rheumatology.oxfordjournals.org/content/42/suppl_1/144.full.pdf

Rank receptor and HIV (thrombopoietin-like receptor and retrovirus)
http://www.ncbi.nlm.nih.gov/pubmed/22842843

Sjogren's syndrome is an autoimmune disease of the moisture producing glands

salivary secretion inhibited by activation of cannabinoid receptors
 I suspect HPV viruses for some cases
http://www.ncbi.nlm.nih.gov/pubmed/16946411

high rates of HPV with sjogren's patients?
http://www.blackwellpublishing.com/acrmeeting/abstract.asp?MeetingID=781&id=95227

no correlations found here??? hpv and sjogren's
http://www.ncbi.nlm.nih.gov/pubmed/17713098

failure to find HPV in primary sjogren's
http://www.ncbi.nlm.nih.gov/pubmed/10323467

which CB receptors are there?

both CB1 and CB2
http://www.physoc.org/proceedings/abstract/Proc%20Physiol%20Soc%2021PC38
http://www.ncbi.nlm.nih.gov/pubmed/16946411

mainly CB1?
http://www.scielo.cl/pdf/ijmorphol/v33n2/art44.pdf

If CB1 then HPV16?
http://angelabiggs.blogspot.com/2016/08/cannabinoid-receptors-and-human.html

HPV16 and EBV in salivary cancer
http://www.ncbi.nlm.nih.gov/pubmed/27547238

erosive oral lichen and hpv16
http://www.pasteur.fr/en/institut-pasteur/press/press-documents/human-papillomavirus-linked-auto-immune-disease

EOL and sjogren's
http://www.ncbi.nlm.nih.gov/pubmed/2018610
http://www.ncbi.nlm.nih.gov/pubmed/2077152

spirochetes and lichen sclerosis
http://www.ncbi.nlm.nih.gov/pubmed/2393064
http://www.ncbi.nlm.nih.gov/pubmed/3192771
http://www.ncbi.nlm.nih.gov/pubmed/10792212
I can't tell if this is truly the lyme spirochete or not.

do spirochetes in humans move to the salivary gland like they do in ticks?

EOL, SJ and hepatitis C?
http://onlinelibrary.wiley.com/doi/10.1111/j.1346-8138.1997.tb02733.x/abstract?systemMessage=Wiley+Online+Library+will+be+unavailable+on+Saturday+3rd+September+2016+at+08.30+BST/+03:30+EDT/+15:30+SGT+for+5+hours+and+Sunday+4th+September+at+10:00+BST/+05:00+EST/+17:00+SGT+for+1+hour++for+essential+maintenance.+Apologies+for+the+inconvenience

http://onlinelibrary.wiley.com/doi/10.1111/j.1346-8138.1995.tb03395.x/full



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