Extremely high IFN with alphaviruses and flaviviruses? is it more than the typical increase because of NS1?

IFN was once called viral inhibitory factor.  

IFNs are the cytokines released by host cells to call the immune system to come fight an infection. IFN is responsible for the "flu like symptoms" of high fever and muscle pains.

However when alphaviruses and flaviviruses are involved it almost seems as if IFN overdosing is occurring. why is IFN so high?

These viruses secrete NS1.

NS1 a protein that these viruses secrete which alters IFN expression
http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0013927

Immediately proceeding infection by alphaviruses " alphavirus-infected cells become unable to respond to IFN-β"
http://www.ncbi.nlm.nih.gov/pubmed/22345447

sindbis virus and IFN receptor mutant mice...died of hemorrhagic fever
http://www.sciencedirect.com/science/article/pii/S0042682207004175

completely blocking IFN stops the hemorrhagic fever
https://www.scripps.edu/newsandviews/e_20140616/baccala.html

IFN was found to be critical for Venezuelan equine encephalitis virus 
http://www.ncbi.nlm.nih.gov/pubmed/11264360

Further when a group attached a green fluorescent protein to Ross River Virus they could see that initially the virus acts through macrophages
http://www.labonline.com.au/content/life-scientist/news/ross-river-study-offers-arthritis-clues-833562532

MCr 1 and MCR3 are on macrophages (see below links to why i think these viruses infect using these receptors)
http://www.ncbi.nlm.nih.gov/pubmed/22566831

IFN gamma is the key macrophage activator
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2630590/

there are 2 pathways a macrophage could go: one increases the inflammatory response and the other decreases the inflammatory response
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4316183/figure/fig01/

binding IFN makes macrophages into type one which does not secrete il-10
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4316183/

il-10 has a strong connection to arthritis where it regulates inflammasome. il-10 is an anti-inflammatory cytokine.
http://arthritis-research.biomedcentral.com/articles/10.1186/s13075-014-0419-y

Inflammasome is a multiprotein complex that triggers inflammation

Alphaviruses/flaviviruses cause severe joint pain and inflammation (through the lack of il-10 when the wave of IFN occurs when the immune system overcomes ns1?)

ns1 increases il-10 (in the flaviviruse dengue initially in infection)
http://www.ncbi.nlm.nih.gov/pubmed/26621477

So in the initial stage, flaviviruses and alphaviruses through ns1 suppresses ifn and increases il-10 in an attempt to block normal viral inflammation.  However somehow the immune system overcomes this ns1 protein and makes massive amounts of IFN.

 IFN has been found in the of RA patients synovial fluid (not connected to this disease but the feature of joint pain with the presence of IFN could be significant)
http://www.ncbi.nlm.nih.gov/pubmed/20166872

alphaviruses can have swollen lymph glands

IFN and lymph node development
http://www.pnas.org/content/100/23/13453.full.pdf

IFN pathways and lipopolysaccharide disrupted by River Ross virus
suppressed
http://www.ncbi.nlm.nih.gov/pubmed/12364588

are there known connections between IFN and alphaviruses : Their replication is sensitive to IFN?
http://www.ncbi.nlm.nih.gov/pubmed/25927359

IFN gamma has an affect on skin and pigment so it has some receptors
http://www.ncbi.nlm.nih.gov/pubmed/14760888

IFN beta medication causing skin rash: erythematous maculopapular rash 
http://www.ncbi.nlm.nih.gov/pubmed/18337427

This maculopapular rash is also called morbilliform, it looks like the measles, and is found in all alphavirus cases.

chikungunya and maculopapular rash
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2856378/

O'nyong-nyong and maculopapular rash
http://wwwnc.cdc.gov/eid/article/20/10/14-0823_article

IFN alpha and chorea
http://www.ncbi.nlm.nih.gov/pubmed/11805273

types of alphaviruses:

chikungunya
ross river
mayaro
Barmah forest
sindbis
o'nyong nyong

alpha virus family tree link
http://www.sciencedirect.com/topics/page/Mayaro_virus

chikungunya
https://www.jci.org/articles/view/40104

high IFN and asthma
https://www.jci.org/articles/view/80911
https://aacijournal.biomedcentral.com/articles/10.1186/1710-1492-8-18
(non-atopic asthma in latin american children?...not related to allergy)

chikungunya and asthma
http://www.ncbi.nlm.nih.gov/pubmed/20513912

the liver has IFN-beta receptors (medical dosing of IFN beta has resulted in liver damage)
http://www.ncbi.nlm.nih.gov/pubmed/16531969

rhabdomyolysis and alphaviruses??? is it caused by the high IFN levels???
http://www.ncbi.nlm.nih.gov/pubmed/20962735 chikunguya
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0000527 chikunguya (muscle satellite cells?)
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3242063/ ross river

rhabdomyolysis after IFNbeta treatment (a known condition from high levels of IFN)
http://www.ncbi.nlm.nih.gov/pubmed/27456881
http://www.ncbi.nlm.nih.gov/pubmed/25008446
http://jnnp.bmj.com/content/72/2/274.1.full
http://www.nature.com/ajg/journal/v98/n4/full/ajg2003222a.html
http://jco.ascopubs.org/content/19/17/3794.full
http://jac.oxfordjournals.org/content/67/1/249.long
http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(97)80091-8/abstract
http://www.msard-journal.com/article/S2211-0348(16)30057-8/abstract

Alphaviruses like flaviviruses use melanocortin receptors to infect.

melatonin protectives against these viruses
http://www.ncbi.nlm.nih.gov/pubmed/14962057

my previous ideas of flaviviruses and melanocortin receptors
http://angelabiggs.blogspot.com/2016/08/do-all-flaviviruses-to-some-degree-bind.html