Wednesday, August 10, 2016

Attempting to match up herpes viruses with estrogen receptors

Are the herpes viruses binding different estrogen receptors?

The locations of the receptors seem to match up with the herpes virus families. (these are not proven associations)

Alpha-herpes viruses: Herpes simplex 1, herpes simplex 2,  herpes zoster : Estrogen-beta receptors (nerves and uterine tissue)

Beta-herpes viruses: CMV, HHV6, HHV7 :  Estrogen-related receptors (CMV binding confirmed)

Gamma-herpes viruses: EBV, HHV8 : Estrogen-alpha receptors (lymphocytes, breast involved)

estrogen alpha receptors on lymphocytes
http://www.ncbi.nlm.nih.gov/pubmed/18569528

Review paper that covered the distinct variations of alpha estrogen receptors (different isoforms)
http://physrev.physiology.org/content/87/3/905

Looking at isoforms could further divide up the virus families even more specifically.

papers referenced with isoforms discoveries

http://emboj.embopress.org/content/19/17/4688?ijkey=05415c28b4fcc9840305690efd14a4351fec1884&keytype2=tf_ipsecsha

http://www.ncbi.nlm.nih.gov/pubmed/16165085?access_num=16165085&link_type=MED&dopt=Abstract

ERalpha 66 and breast cancer and ERalpha 36 is the truncated form
http://www.ncbi.nlm.nih.gov/pubmed/18383888

ERRalpha and CMV (HHV4)
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4284536/

EER is the "estrogen related receptor " which has homology to the estrogen receptor alpha but does not bind estrogen rather estrogen like ligands
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4284536/

HHV8 EREs were found to bind alpha estrogen receptors
http://d-scholarship.pitt.edu/13517/

Estrogen alpha receptor and breast cancer
http://www.ncbi.nlm.nih.gov/pubmed/14973389



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