Are the herpes viruses binding different estrogen receptors?
The locations of the receptors seem to match up with the herpes virus families. (these are not proven associations)
Alpha-herpes viruses: Herpes simplex 1, herpes simplex 2, herpes zoster : Estrogen-beta receptors (nerves and uterine tissue)
Beta-herpes viruses: CMV, HHV6, HHV7 : Estrogen-related receptors (CMV binding confirmed)
Gamma-herpes viruses: EBV, HHV8 : Estrogen-alpha receptors (lymphocytes, breast involved)
estrogen alpha receptors on lymphocytes
http://www.ncbi.nlm.nih.gov/pubmed/18569528
Review paper that covered the distinct variations of alpha estrogen receptors (different isoforms)
http://physrev.physiology.org/content/87/3/905
Looking at isoforms could further divide up the virus families even more specifically.
papers referenced with isoforms discoveries
http://emboj.embopress.org/content/19/17/4688?ijkey=05415c28b4fcc9840305690efd14a4351fec1884&keytype2=tf_ipsecsha
http://www.ncbi.nlm.nih.gov/pubmed/16165085?access_num=16165085&link_type=MED&dopt=Abstract
ERalpha 66 and breast cancer and ERalpha 36 is the truncated form
http://www.ncbi.nlm.nih.gov/pubmed/18383888
ERRalpha and CMV (HHV4)
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4284536/
EER is the "estrogen related receptor " which has homology to the estrogen receptor alpha but does not bind estrogen rather estrogen like ligands
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4284536/
HHV8 EREs were found to bind alpha estrogen receptors
http://d-scholarship.pitt.edu/13517/
Estrogen alpha receptor and breast cancer
http://www.ncbi.nlm.nih.gov/pubmed/14973389
The locations of the receptors seem to match up with the herpes virus families. (these are not proven associations)
Alpha-herpes viruses: Herpes simplex 1, herpes simplex 2, herpes zoster : Estrogen-beta receptors (nerves and uterine tissue)
Beta-herpes viruses: CMV, HHV6, HHV7 : Estrogen-related receptors (CMV binding confirmed)
Gamma-herpes viruses: EBV, HHV8 : Estrogen-alpha receptors (lymphocytes, breast involved)
estrogen alpha receptors on lymphocytes
http://www.ncbi.nlm.nih.gov/pubmed/18569528
Review paper that covered the distinct variations of alpha estrogen receptors (different isoforms)
http://physrev.physiology.org/content/87/3/905
Looking at isoforms could further divide up the virus families even more specifically.
papers referenced with isoforms discoveries
http://emboj.embopress.org/content/19/17/4688?ijkey=05415c28b4fcc9840305690efd14a4351fec1884&keytype2=tf_ipsecsha
http://www.ncbi.nlm.nih.gov/pubmed/16165085?access_num=16165085&link_type=MED&dopt=Abstract
ERalpha 66 and breast cancer and ERalpha 36 is the truncated form
http://www.ncbi.nlm.nih.gov/pubmed/18383888
ERRalpha and CMV (HHV4)
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4284536/
EER is the "estrogen related receptor " which has homology to the estrogen receptor alpha but does not bind estrogen rather estrogen like ligands
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4284536/
HHV8 EREs were found to bind alpha estrogen receptors
http://d-scholarship.pitt.edu/13517/
Estrogen alpha receptor and breast cancer
http://www.ncbi.nlm.nih.gov/pubmed/14973389
No comments:
Post a Comment