The autoimmune hypothesis of this blog suggests that it is the cross-targeting of infections on one tissue that triggers autoimmune disease. In the case of lupus the larger outer infection could be a type of aspergillus fungus.
lupus and aspergillus
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3768502/
http://www.ncbi.nlm.nih.gov/pubmed/8720197
http://www.ncbi.nlm.nih.gov/pubmed/12090570
http://www.ncbi.nlm.nih.gov/pubmed/12412216
http://www.ncbi.nlm.nih.gov/pubmed/8989808
http://www.ncbi.nlm.nih.gov/pubmed/9352608
multisystem sarcoidosis and aspergillus
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3116216/
Scotland has high levels of Pernio
The most common aspergillus in Scotland is A. parasiticus (61%)
http://www.ncbi.nlm.nih.gov/pubmed/23416649
This is a hypothesis that A.parasiticus specifically causes pernio.
Chilblain aka pernio
https://en.wikipedia.org/wiki/Chilblains
http://www.ncbi.nlm.nih.gov/pubmed/2212122
appears to overlap with sarcoidosis
http://www.ncbi.nlm.nih.gov/pubmed/27222775
lupus pernio from infliximab
http://www.ncbi.nlm.nih.gov/pubmed/26147319
infliximab /Remacade : drug used against TNF-alpha in autoimmune diseases
https://en.wikipedia.org/wiki/Infliximab
Aspirin and TNF-alpha
http://www.ncbi.nlm.nih.gov/pubmed/15036249
high TNF-alpha is involved with sarcoidosis
http://www.ncbi.nlm.nih.gov/pubmed/14746631
mixed connective tissue disease: SLE with Scleroderma and polymyositis
http://rarediseases.org/rare-diseases/mixed-connective-tissue-disease-mctd/
Lupus can be triggered by TNF-alpha inhibitors!
lupus/neck pain with the butterfly rash across face: tiny blood vessels
http://www.lupusresearch.org/lupus/symptoms.html?referrer=https://www.google.com/#.V4uG6JOAOkp
What causes this contraction of the blood vessels?
Quorums are the communication molecules infections use.
What are Aspergillus' quorums: ACTH? tyrosol? A. niger also has aflatoxin.
ACTH would disrupt the adrenal glands
aspergillus and ACTH
http://www.ncbi.nlm.nih.gov/pubmed/23967728
addison's disease and SLE (uncommon but there)
http://www.ncbi.nlm.nih.gov/pubmed/25400892
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3952287/
http://www.ncbi.nlm.nih.gov/pubmed/9228146
adrenal involvement in anti-phospholipid syndrome
http://www.ncbi.nlm.nih.gov/pubmed/12640187
Lupus and anti-phospholipid syndrome
http://jasn.asnjournals.org/content/18/9/2461.full
Previous blog linked addison's and the fungus candida together through farsenol
http://angelabiggs.blogspot.com/2015/12/candidas-quorum-sensing-and-addisons.html
The quorum tyrosol would cause pigment issues (if secreted by aspergillus) and could also cause the blood vessel contraction/ dilation
Chilblains is a blood circulation issue where damage occurs to blood vessels due to cold.
Normally cold exposure cases vasoconstriction where blood is pulled away from skin. Warm exposure then triggers Vasculitis where the blood vessels expand.
An excessive amount of tyrosol inducing dilation of vessels could prevent the normal vasoconstriction during exposure to cold. Thus the hands or feet would look purple and swell.
Chilblian lupus and discord lupus overlap
https://www.derm101.com/dpc-archive/january-march-1999-volume-5-no-1/dpc0501a20-pernio-perniosis-lupus-pernio-chilblain-chilblain-lupus/
Previous post about a different fungus Trichophyton and tyrosol (discord lupus)
http://angelabiggs.blogspot.com/2016/02/tyrosol-as-quorum-of-trichophyton.html
The difference here is where the fungus hangs out: trichophyton infects the skin where as aspergillus parasiticus infects inside the body often the lungs
tyrosol from Aspergillus in soy
https://books.google.com/books?id=-M5t2nXIXi4C&pg=PA636&lpg=PA636&dq=tyrosol+vessels&source=bl&ots=7IxkWckjs8&sig=F9mu2_o7oSUR5qOnXxKETTPoM48&hl=en&sa=X&ved=0ahUKEwj0sa203PrNAhVqzoMKHXsDC_sQ6AEITTAJ#v=onepage&q=tyrosol%20vessels&f=false
Do the forms of lupus that occur in japan have a distinctive pigment issue? or are we seeing that these fungus prefer to grow in different locations: aspergillus inside the body while trichophyton prefers the skin
lupus and aspergillus
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3768502/
http://www.ncbi.nlm.nih.gov/pubmed/8720197
http://www.ncbi.nlm.nih.gov/pubmed/12090570
http://www.ncbi.nlm.nih.gov/pubmed/12412216
http://www.ncbi.nlm.nih.gov/pubmed/8989808
http://www.ncbi.nlm.nih.gov/pubmed/9352608
multisystem sarcoidosis and aspergillus
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3116216/
Scotland has high levels of Pernio
The most common aspergillus in Scotland is A. parasiticus (61%)
http://www.ncbi.nlm.nih.gov/pubmed/23416649
This is a hypothesis that A.parasiticus specifically causes pernio.
Chilblain aka pernio
https://en.wikipedia.org/wiki/Chilblains
http://www.ncbi.nlm.nih.gov/pubmed/2212122
appears to overlap with sarcoidosis
http://www.ncbi.nlm.nih.gov/pubmed/27222775
lupus pernio from infliximab
http://www.ncbi.nlm.nih.gov/pubmed/26147319
infliximab /Remacade : drug used against TNF-alpha in autoimmune diseases
https://en.wikipedia.org/wiki/Infliximab
Aspirin and TNF-alpha
http://www.ncbi.nlm.nih.gov/pubmed/15036249
high TNF-alpha is involved with sarcoidosis
http://www.ncbi.nlm.nih.gov/pubmed/14746631
mixed connective tissue disease: SLE with Scleroderma and polymyositis
http://rarediseases.org/rare-diseases/mixed-connective-tissue-disease-mctd/
Lupus can be triggered by TNF-alpha inhibitors!
lupus/neck pain with the butterfly rash across face: tiny blood vessels
http://www.lupusresearch.org/lupus/symptoms.html?referrer=https://www.google.com/#.V4uG6JOAOkp
What causes this contraction of the blood vessels?
Quorums are the communication molecules infections use.
What are Aspergillus' quorums: ACTH? tyrosol? A. niger also has aflatoxin.
ACTH would disrupt the adrenal glands
aspergillus and ACTH
http://www.ncbi.nlm.nih.gov/pubmed/23967728
addison's disease and SLE (uncommon but there)
http://www.ncbi.nlm.nih.gov/pubmed/25400892
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3952287/
http://www.ncbi.nlm.nih.gov/pubmed/9228146
adrenal involvement in anti-phospholipid syndrome
http://www.ncbi.nlm.nih.gov/pubmed/12640187
Lupus and anti-phospholipid syndrome
http://jasn.asnjournals.org/content/18/9/2461.full
Previous blog linked addison's and the fungus candida together through farsenol
http://angelabiggs.blogspot.com/2015/12/candidas-quorum-sensing-and-addisons.html
The quorum tyrosol would cause pigment issues (if secreted by aspergillus) and could also cause the blood vessel contraction/ dilation
Chilblains is a blood circulation issue where damage occurs to blood vessels due to cold.
Normally cold exposure cases vasoconstriction where blood is pulled away from skin. Warm exposure then triggers Vasculitis where the blood vessels expand.
An excessive amount of tyrosol inducing dilation of vessels could prevent the normal vasoconstriction during exposure to cold. Thus the hands or feet would look purple and swell.
Chilblian lupus and discord lupus overlap
https://www.derm101.com/dpc-archive/january-march-1999-volume-5-no-1/dpc0501a20-pernio-perniosis-lupus-pernio-chilblain-chilblain-lupus/
Previous post about a different fungus Trichophyton and tyrosol (discord lupus)
http://angelabiggs.blogspot.com/2016/02/tyrosol-as-quorum-of-trichophyton.html
The difference here is where the fungus hangs out: trichophyton infects the skin where as aspergillus parasiticus infects inside the body often the lungs
tyrosol from Aspergillus in soy
https://books.google.com/books?id=-M5t2nXIXi4C&pg=PA636&lpg=PA636&dq=tyrosol+vessels&source=bl&ots=7IxkWckjs8&sig=F9mu2_o7oSUR5qOnXxKETTPoM48&hl=en&sa=X&ved=0ahUKEwj0sa203PrNAhVqzoMKHXsDC_sQ6AEITTAJ#v=onepage&q=tyrosol%20vessels&f=false
Do the forms of lupus that occur in japan have a distinctive pigment issue? or are we seeing that these fungus prefer to grow in different locations: aspergillus inside the body while trichophyton prefers the skin
Aflotoxin from A.niger I had been looking at as a trigger for Pick's dieseases Tau protein
lupus and pick's disease
No comments:
Post a Comment