Monday, July 18, 2016

Subacute cutaneous lupus erythematosus, Aspergillus fumigatus, and gliotoxins


Subacute cutaneous lupus erythematosus and aspergillus fumigatus
http://www.ncbi.nlm.nih.gov/pubmed/18374855
http://www.ncbi.nlm.nih.gov/pubmed/7894223 (pneumonia)

lupus and aspergillus fumigatus with increased granulocytopenia
http://www.ncbi.nlm.nih.gov/pubmed/7604298

Granulocytopenia (a type of white blood cells )
https://en.wikipedia.org/wiki/Granulocyte#Pathology

Does the toxin that aspergillus secretes cause this condition of granulocytopenia in lupus?

Aspergillus fumigatus secretes gliotoxin ab immune suppressing toxin
http://www.ncbi.nlm.nih.gov/pubmed/17574915
http://www.bloodjournal.org/content/105/6/2258?sso-checked=true
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2708386/

some lupus has sun sensitivity
http://emedicine.medscape.com/article/1065657-overview

Gliotoxin inhibits Farnesyltransferase
https://link.springer.com/article/10.1385/MO:21:1:21

Rash and inhibition of farnesyltransferase
http://onlinelibrary.wiley.com/store/10.1002/cncr.23078/asset/23078_ftp.pdf?v=1&t=jeu2bcuc&s=874bb318f5b62fb928cc2d0fa7942c375de01181

How does the rash occur?? Is it gliotoxin directly broken down or gliotoxins's inhibition of Farnesyltransferase ?

note that gliotoxin contains a disulfide bridge
http://www.ncbi.nlm.nih.gov/pubmed/15584558

sun exposure damages disulfide bridges
http://marketplace.yet2.com/app/insight/needofweek/6244?sid=350








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