A scientific paradigm shift occurs when current assumptions are suddenly realized to be either wrong or "off" enough that when a new hypothesis appears based on different assumptions that when tested explains more, predicts more, and thus creates a fundamental shift in the field.
Cancer's paradigm shift
Lately the assumption in cancer has been that DNA damage causes cancer however patterns exist that favor Francis Peyton Rous' older hypothesis that "co-carcinogenesis" causes cancer. We now know there are cancers that seem to appear together, prostate and skin cancer, if that is a true relationship how can it be random DNA damage? Rous believed a carcinogen and a virus together causes cancer not DNA damage and conducted the first experiments to prove this.
My co-carcinogenesis hypothesis takes his further: Carcinogens inhibit polymerases.
Yes we have been told carcinogens cause DNA damage but I think their ability to inhibit polymerases causes most cancer. All carcinogens have already been found to inhibit polymerases. Further it is already known which cell types the carcinogens infect. The cancers have patterns and are not that chaotic.
Alone a carcinogen would inhibit growth until a virus appears opens up the DNA and modifies the cell's telomeres to create virus supplies forever. This inhibiting of growth is what we see with too much carcinogens for example too much benzene in bone marrow and the person becomes anemic.
Yes we have been told carcinogens cause DNA damage but I think their ability to inhibit polymerases causes most cancer. All carcinogens have already been found to inhibit polymerases. Further it is already known which cell types the carcinogens infect. The cancers have patterns and are not that chaotic.
Alone a carcinogen would inhibit growth until a virus appears opens up the DNA and modifies the cell's telomeres to create virus supplies forever. This inhibiting of growth is what we see with too much carcinogens for example too much benzene in bone marrow and the person becomes anemic.
Cancer occurs because a carcinogen inhibits the viral polymerase better than the human polymerase. When a virus infects the same cell as a carcinogen they interact. Instead of the virus making what it wants in the host the infected cell is transformed into a cancer cell by the carcinogen.
Autoimmune Diseases' paradigm shift
Currently it is believed that autoimmune diseases are chaotic and slowly developed. As if the immune system slowly becomes crazy through inflammation and genetic defect. However patterns exist that suggest quite the opposite that autoimmune disease is triggered suddenly and most importantly is a predictable occurrence.
If you look at the Autoimmune diseases that occur together and look for a shared infection you find areas of overlap. Sjogren's, Hoshimoto's thyroid, and type one diabetes have all been linked to fungal infections.
However different infections can trigger the same disease: coxsackie or the flu can trigger type 1 diabetes which seems to say the specific infection is not important and it is an immune system dysfunction that is critical.
So here is the paradigm shift: the infections exist for a while in the host but the infections themselves to not slowly lead up to the autoimmune disease rather the immediate dysfunction of the immune system faced with "autoimmune cross-targeting" triggers autoimmune disease.
Autoimmune cross-targeting hypothesis suggests that simultaneous infections on one target triggers autoimmunity. One infection on the outside of the target cell and one infection, like a virus, on the inside of the target. Note that chemicals and drugs can replace an infection as foreign to the immune system.
This blog has been going through the cancers and autoimmune diseases testing these hypotheses and I am at the point now where I can say....prepare yourself for HUGE paradigm shifts.
Happy 4th of July! Let's have a huge boom today...please share this!
No comments:
Post a Comment