Friday, July 1, 2016

Do retroviruses use the thrombopoietin receptors?

Chronic myeloid leukemia and HIV?  rare?
http://www.ncbi.nlm.nih.gov/pubmed/22527850
http://www.ncbi.nlm.nih.gov/pubmed/22867899
http://www.ncbi.nlm.nih.gov/pubmed/18452074

Thrombopoietin receptors and CML Chronic myeloid leukemia
http://onlinelibrary.wiley.com/doi/10.1002/(SICI)1097-0142(20000201)88:3%3C570::AID-CNCR12%3E3.0.CO;2-I/full

Thrombopoietin receptors and HIV infections?

Thrombocytopenia in HIV
http://www.ncbi.nlm.nih.gov/pubmed/16454716
http://www.ncbi.nlm.nih.gov/pubmed/9616135

liver and HIV
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2997131/

Kidney and HIV
http://hivinsite.ucsf.edu/InSite?page=kb-00&doc=kb-04-01-10

TPO
http://www.bloodjournal.org/content/98/12/3241?sso-checked=true

Thrombopoietin is made by liver, kidney, and bone marrow cells..all of which we see infected by HIV


what about other retroviruses? do they infect the same type of cells?

rous sarcoma virus and kidney cells
http://www.ncbi.nlm.nih.gov/pubmed/3015940

rous sarcoma virus and liver cells
http://www.ncbi.nlm.nih.gov/pubmed/2177729

Further note that 70% of people with HIV have sleep issues
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3543776/

Thrombopoietin production is controlled  by the circadian sleep/wake cycle
http://onlinelibrary.wiley.com/doi/10.1111/j.1538-7836.2012.04643.x/abstract

mplv, a retrovirus, has been linked to the thrombopoietin receptor by the thrombopoietin-like protein it makes

https://books.google.com/books?id=bfPORhG6DP8C&pg=PT139&lpg=PT139&dq=htlv+retrovirus+Thrombopoietin&source=bl&ots=bUDYfErtXg&sig=v5KvUb0mtaFqeQUPuUz_rCaAKVE&hl=en&sa=X&ved=0ahUKEwibjMH7hNPNAhVB8GMKHSl-AtMQ6AEIaTAJ#v=onepage&q=htlv%20retrovirus%20Thrombopoietin&f=false

why would the virus make this protein? Is this how it binds the receptors?


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