Co-carcinogenesis : Rous' hypothesis requires a virus and a carcinogen together to start cancer.
My co-carcinogenesis takes his further: Carcinogens inhibit polymerases.
(yes we have been told carcinogens cause DNA damage but I think their ability to inhibit polymerases causes most cancer. The cancers have patterns and are not that chaotic)
Alone a carcinogen would inhibit growth until a virus appears opens up the DNA and modifies the cell to create virus supplies for ever. The problem is the carcinogen inhibits the viral polymerase better than the human polymerase. So instead of the virus making what it wants the infected cell is transformed into a cancer cell.
There are 4 types of leukemia and they are associated with different viruses
Acute myeloid leukemia AML and flaviviruses
Chronic myeloid leukemia CML and the HIV virus
HIV and CML
http://www.ncbi.nlm.nih.gov/pubmed/18452074
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3932605/
http://www.ncbi.nlm.nih.gov/pubmed/11361394
https://www.researchgate.net/publication/224820749_Chronic_myeloid_leukaemia_and_human_immunodeficiency_virus_HIV_infection
(HIV is a retrovirus and they may use gangliosides )
Acute lymphocyte leukemia ALL and HTLV viruses (involves t-cells)
HTLV-1
http://www.lymphoma.org/atf/cf/%7B0363cdd6-51b5-427b-be48-e6af871acec9%7D/htlv.pdf
http://emedicine.medscape.com/article/219285-overview
HTLV-2 and hairy cell leukemia
http://science.sciencemag.org/content/218/4572/571.long
feline leukemia virus is a retrovirus
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3509668/
mice have a version of these: murine leukemia virus
https://en.wikipedia.org/wiki/Murine_leukemia_virus
a new type of murine virus has been suspected of infecting people: xenotrophic murine leukemia virus
http://jid.oxfordjournals.org/content/202/10/1463.full
koalas have leukemia causing retroviruses
https://retrovirology.biomedcentral.com/articles/10.1186/1742-4690-10-108
Chronic lymphocytic leukemia CLL and HPV viruses
My co-carcinogenesis takes his further: Carcinogens inhibit polymerases.
(yes we have been told carcinogens cause DNA damage but I think their ability to inhibit polymerases causes most cancer. The cancers have patterns and are not that chaotic)
Alone a carcinogen would inhibit growth until a virus appears opens up the DNA and modifies the cell to create virus supplies for ever. The problem is the carcinogen inhibits the viral polymerase better than the human polymerase. So instead of the virus making what it wants the infected cell is transformed into a cancer cell.
There are 4 types of leukemia and they are associated with different viruses
Acute myeloid leukemia AML and flaviviruses
AML and dengue virus
west nile and leukemia
http://www.ncbi.nlm.nih.gov/pubmed/16344671
http://journals.lww.com/jpho-online/Abstract/2005/12000/West_Nile_Virus_Infection_in_a_Teenage_Boy_With.6.aspx
http://wwwnc.cdc.gov/eid/article/7/4/01-7432_article ?
http://www.auntminnie.com/index.aspx?sec=ser&sub=def&pag=dis&ItemID=56900?
Hepatitis C and acute leukemia
http://www.ncbi.nlm.nih.gov/pubmed/8037177
(Flaviviruses might be using melanocortin receptors)
http://www.ncbi.nlm.nih.gov/pubmed/16344671
http://journals.lww.com/jpho-online/Abstract/2005/12000/West_Nile_Virus_Infection_in_a_Teenage_Boy_With.6.aspx
http://wwwnc.cdc.gov/eid/article/7/4/01-7432_article ?
http://www.auntminnie.com/index.aspx?sec=ser&sub=def&pag=dis&ItemID=56900?
Hepatitis C and acute leukemia
http://www.ncbi.nlm.nih.gov/pubmed/8037177
(Flaviviruses might be using melanocortin receptors)
Chronic myeloid leukemia CML and the HIV virus
HIV and CML
http://www.ncbi.nlm.nih.gov/pubmed/18452074
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3932605/
http://www.ncbi.nlm.nih.gov/pubmed/11361394
https://www.researchgate.net/publication/224820749_Chronic_myeloid_leukaemia_and_human_immunodeficiency_virus_HIV_infection
(HIV is a retrovirus and they may use gangliosides )
Acute lymphocyte leukemia ALL and HTLV viruses (involves t-cells)
HTLV-1
http://www.lymphoma.org/atf/cf/%7B0363cdd6-51b5-427b-be48-e6af871acec9%7D/htlv.pdf
http://emedicine.medscape.com/article/219285-overview
HTLV-2 and hairy cell leukemia
http://science.sciencemag.org/content/218/4572/571.long
feline leukemia virus is a retrovirus
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3509668/
mice have a version of these: murine leukemia virus
https://en.wikipedia.org/wiki/Murine_leukemia_virus
a new type of murine virus has been suspected of infecting people: xenotrophic murine leukemia virus
http://jid.oxfordjournals.org/content/202/10/1463.full
koalas have leukemia causing retroviruses
https://retrovirology.biomedcentral.com/articles/10.1186/1742-4690-10-108
Chronic lymphocytic leukemia CLL and HPV viruses
lymphocytic leukemia (CLL) and cervical cancer
CLL and HPV
(HPV viruses may use the cannabinoid receptors and this group may be the group that cannabinoid, marijuana, helps)
I will read it again, once my brain is not so tired. :)
ReplyDeleteThis comment has been removed by a blog administrator.
ReplyDelete