Tuesday, September 13, 2016

Do Paramyxoviridae (measles family viruses) bind Muscarinic receptors?


Enteroviruses (coxsackie, polio etc) may bind nicotine receptors
http://angelabiggs.blogspot.com/2016/08/enteroviruses-and-nicotine.html

Nectin-like interactions of polio virus binding
http://www.ncbi.nlm.nih.gov/pubmed/25631086

Measles virus binds nectin-4
http://www.ncbi.nlm.nih.gov/pubmed/27483301

since polio virus binds nectins and measles binds nectin 4 is it possible that paramyxoviridae viruses bind muscarinic receptors?

do measles bind muscarinic receptors? Muscarinic receptors are found on smooth muscles.

eye and bladder have muscarinic receptors

neurogenic bladder after measles
http://www.ncbi.nlm.nih.gov/pubmed/2087429

bladder and muscarinic receptors
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1751864/

Measles is the leading cause of childhood blindness !!!

Measles issues: croupy cough, loss of voice, swelling eyes, uncontrolled salivation

M1 receptors and eye development
https://www.ncbi.nlm.nih.gov/pubmed/20964868

joints and muscarinic receptors?
http://www.sciencedirect.com/science/article/pii/036192309190296V

measles and smooth muscle antibodies in joint of RA
http://ard.bmj.com/content/36/4/302.full.pdf+html
http://www.ncbi.nlm.nih.gov/pubmed/901028

muscarinic receptors and the cerebellum
http://www.ncbi.nlm.nih.gov/pubmed/23776234

M3 and cerebellum?
http://www.ncbi.nlm.nih.gov/pubmed/26823384

cerebellum type 2 and 3 muscarinic receptors
http://www.ncbi.nlm.nih.gov/pubmed/18358697

measles and cerebellum
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC375852/

parainfluenza viruses
https://en.wikipedia.org/wiki/Human_parainfluenza_viruses

HPIV 1 and 2 cause CROUP

M2 receptors and croup?
https://www.ncbi.nlm.nih.gov/pubmed?term=9649578

HPIV 3 Bronchiolitis ( inflammation of the bronchioles)

Bronchioles have M3 receptors
https://en.wikipedia.org/wiki/Bronchoconstriction

Can't clearly match up viruses and muscarinic receptors: measles virus could bind more than one type?

Kids who had RSV can later have asthmatic reactions to viral infections...why?

eosinphils express muscarini receptors (M2)
http://digitalcommons.ohsu.edu/etd/540/

RSV and eosinphils: eosinphils as targets of infection
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2741084/

eosinphils and measles (eosinphils increased)
http://jid.oxfordjournals.org/content/180/4/950.full

Are they increased to counter the numbers of eosinphils infected by the virus?

increased eosinphils in bronchial asthma
http://www.ncbi.nlm.nih.gov/pubmed/2215562

has the immune system adapted because of the RSV and started making more eosinphils each time?

Note that eosinphils are required for the development of plasma cells
http://www.ncbi.nlm.nih.gov/pubmed/21217761

Could doses of measles destroy eosinphil populations?

A woman was cured of plasma cell cell cancer (Myeloma) by measles virus treatments
http://www.medicalnewstoday.com/articles/276966.php

How did they "engineer" these cancer treatment measle viruses? could they infect cells but not replicate?










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