Friday, July 31, 2015

Is bipolar disorder an autoimmune disorder of the anterior cingulate?

Autoimmune cross-targeting hypothesis: a virus marks the inside of a cell while a larger infection marks the outside and the combination triggers autoimmune disease.  The immune system is instructed to destroy both the inside and the outside of the target.

Is bipolar autoimmune? This paper suggests it might be.
http://www.ncbi.nlm.nih.gov/pubmed/24557044

If autoimmune cross-targeting is occurring in bipolar then is the target the anterior cingulate with CMV marking the inside the a larger infection like mycobacteria or t.gondii marking the outside? T.gondii causing type 1 bipolar. Mycobacterias causing type 2 bipolar.

Anterior cingulate is the region of the brain which communicates the frontal lobe and the amgydala. In a way it dampens the reactions and gives the lobe time to think about how to respond
https://en.wikipedia.org/wiki/Anterior_cingulate_cortex

anterior cingulate and bipoar
http://www.ncbi.nlm.nih.gov/pubmed/17924244
http://www.ncbi.nlm.nih.gov/pubmed/19407272
http://www.biologicalpsychiatryjournal.com/article/S0006-3223(04)00767-X/abstract

Here is an image of CMV in the brain
http://www.neurology.org/content/70/1/84.full.pdf
which show the lateral ventricles are infected but if the infection also involves the anterior cingulate i can't tell

CMV and bipolar
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4444593/
http://www.hindawi.com/journals/np/2015/939780/
http://www.ncbi.nlm.nih.gov/pubmed/24083998
http://www.psychiatrictimes.com/articles/infectious-agents-schizophrenia-and-bipolar-disorder
http://platform.wotmed.com/WotmedNews/news/cytomegalovirus-antibody-elevation-in-bipolar-disorder-relation-to-elevated-mood-states


Bipolar 1 is manic depressive.  Bipolar 2 has less up mania and more depression.

Bipolar 1 : CMV and t.gondii?

bipolar 1 , alcohol use, anxiety
http://www.ncbi.nlm.nih.gov/pubmed/16669730
http://www.ncbi.nlm.nih.gov/pubmed/18199243

t.gondii, anxiety, bipolar 1
http://www.ncbi.nlm.nih.gov/pubmed/24102676
http://www.ncbi.nlm.nih.gov/pubmed/25185399
http://www.ncbi.nlm.nih.gov/pubmed/22325983

Bipolar 2: CMV and other bacterial or mycobacteria infections?

Psoriasis and bipolar...(mycobacterias)
http://www.medscape.com/viewarticle/718347

Parkinson's and bipolar (mycobacteria)
http://www.ncbi.nlm.nih.gov/pubmed/22162696

tourettes and type 2 bipolar (strep or mycobacteria?)
http://neuro.psychiatryonline.org/doi/abs/10.1176/jnp.23.1.jnpe26

metabolic syndrome in bipolar
http://www.ncbi.nlm.nih.gov/pubmed/27287788

Mycobacteria's quorum is cGMP which links it to type 2 diabetes and fatty acid liver disease
http://angelabiggs.blogspot.com/2015/12/mycobacterias-possible-connection-to.html 
http://angelabiggs.blogspot.com/2015/12/the-conundrum-of-high-cholesterol-type2.html

Testosterone levels can also become lower with this condition
http://www.ncbi.nlm.nih.gov/pubmed/23797822?dopt=Abstract&holding=f1000,f1000m,isrctn







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