Tuesday, July 28, 2015

Celiac disease and cross-targeting triggering autoimmunity

Autoimmune Hypothesis:
Cross-targeting of the immune system by a viral infection marking the inside of a host cell and second infection marking the outside of the host cell causes autoimmune disease where the organ is attacked.  In the case of Celiac disease: Antibodies against e.coli mark the outside of the intestine then an intestinal virus (adenovirus or hepatitis) infection marks the inside of the intestinal cells.

Dermatitis Herpetiformis has been correlated with Celiac.  25% of patients with Celiac disease have  HD.
http://celiac.nih.gov/Dermatitis.aspx

E.coli causes small intestine infections
http://www.pathologyoutlines.com/topic/smallbowelEcoli.html

 The e.coli of bladder infections is the same e.coli of skin infections 
http://jcm.asm.org/content/47/6/1811

 Bladder Infections and celiac disease in children
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1511510/

Celiac viral infections: hepatitis and adenoviruses (mono)
http://www.sciencedirect.com/science/article/pii/S1568997208002012
http://www.ncbi.nlm.nih.gov/pubmed/25212692
http://www.ncbi.nlm.nih.gov/pubmed/15492610
http://www.ncbi.nlm.nih.gov/pubmed/23982094

Celiac disease found in hepatitis patients
http://www.ncbi.nlm.nih.gov/pubmed/15645466

89% of celiacs had antibodies suggesting previous adenovirus infection
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1433141/

Hepatitis C and celiac
http://www.ncbi.nlm.nih.gov/pubmed/21180248

hepatitis C can infect the intestine
http://www.ncbi.nlm.nih.gov/pubmed/15302945

Hepatitis A in liver and intestine of marmosets
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC550891/

C.jejuni and celiac
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2657967/
can this replace the e.coli?


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