Sunday, July 19, 2015

Looking at the areas of overlap between Alzheimer's and RA

I am looking at the dementia of the frontal lobe because RA has antibodies that are targeted there. Previously, I suggested that RA was an autoimmune disease triggered by the cross-targeting of epstein barr and mycoplasmas.  If the blood brain barrier breaks down and these infections get into the brain could this explain frontal lobe dementia? I can imagine 3 scenarios: the herpes virus causing classic alzheimer's damage of the neuron's mitochondria,  an autoimmune cross-targeting inflammation of the frontal lobe, and the vascular issues caused by the mycoplasmas.

Autoimmune cross-targeting hypothesis: a virus marks the inside of a cell while a larger infection marks the outside and the combination triggers autoimmune disease.  The immune system is instructed to destroy both the inside and the outside of the target.

It is going to take some time to figure out what is exactly going on.  Epstein barr is HHV6 which is a type of herpes virus.

For RA cross-targeting I had epstein barr or hepatitis on the inside then mycoplasmas on the outside of host tissue. (link to older post is at the bottom)

Alzheimer dementia vs non alzeimer's?
http://www.ncbi.nlm.nih.gov/pubmed/9681642

Early onset Alzheimer's has apraxia and language problems
http://www.ncbi.nlm.nih.gov/pubmed/20061618/

apraxia involves the frontal lobe

Alzheimer's and RA : the confusing relationship
http://www.ncbi.nlm.nih.gov/pubmed/23272690

Epstein barr virus and alzheimer's
http://www.ncbi.nlm.nih.gov/pubmed/23916950

The question is....does epstein barr infect the frontal lobe or do we need to wait for a flu virus? If we say that RA is cross-targeting of epstein barr and mycoplasmas could the frontal lobe autoimmunity be the flu and mycoplasmas or is it still epstein barr?

Frontal lobe and the flu virus
http://www.ncbi.nlm.nih.gov/pubmed/10788752
http://www.ncbi.nlm.nih.gov/pubmed/22711342

Frontal lobe dementia: semantic type and herpes virus
http://www.ncbi.nlm.nih.gov/pubmed/17251241

Frontal lobe infection by mycoplasma
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3873169/

mycoplasmas and vascular disease in turkeys
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC433539/

Epstein barr and rheumatoid arthritis
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1526553/

mycoplasmas and rheumatoid
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1006269/?page=1

10% of dyslexics had rheumatoid arthritis
http://www.nytimes.com/1994/10/18/science/researchers-find-gene-that-may-link-dyslexia-with-immune-disorders.html

dyslexia and the frontal lobe
http://www.ldonline.org/article/14907/

attentional dyslexia and alzheimer's
http://www.tandfonline.com/doi/abs/10.1080/026432996382006#.VawTuK6UzGc

Is there an overlap of dyslexia and apraxia?

Lupus vs MS....it's more of a vascular disease
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2572265/

mycoplasmas and vascular growth factor
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3283799/

vascular growth factor and fatty acids
http://www.ncbi.nlm.nih.gov/pubmed/23455771

vascular dementia (not alzheimer's)
http://www.helpguide.org/articles/alzheimers-dementia/vascular-dementia.htm
not all vascular dementia will be linked here

pediatric encephalitis and mycoplasmas
http://www.medscape.com/viewarticle/566304

unusual in adults?

Corticosteroids used against mycoplasmas for encephalitis
http://content.iospress.com/articles/journal-of-pediatric-infectious-diseases/jpi00315

high dose steroids aid in mycoplasma recovery
http://www.medpagetoday.com/InfectiousDisease/Pneumonia/11340

my previous posts on RA cross-targeting
http://angelabiggs.blogspot.com/2014/11/autoimmune-cross-targeting-could-cause.html

My previous post about autism where the child is born with autism.  RA and the Flu increases the chances a child is born with autism. This is not the regressive form of autism. Is this autism caused by autoimmunity cross-targeting of the frontal lobe in a developing baby while the woman is pregnant?
http://angelabiggs.blogspot.com/2015/02/maternal-antibodies-causes-one-form-of.html



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