Rheumatoid arthritis as an autoimmune disease of the mother can effect the unborn child.
A reason to keep inflammation down while pregnant and a huge reason to get flu shots multiple years before planning a pregnancy.
Autoimmune cross-targeting hypothesis:
The cross-targeting of 2 infections on one target triggers autoimmunity. A virus marks the inside and a different infection marks the outside. The target is clearly important in determining which autoimmune disease develops. In this case the mycoplasmas of RA produce antibodies against the frontal lobe. Normally the blood brain barrier protects the brain but this is not fully developed in an embryo. If the pregnant mother with RA catches the flu virus cross-targeting on the frontal lobe can occur because the flu virus when it has access to the brain replicates in the frontal lobe. The outside and the inside of the baby's frontal lobe's neurons are attacked by the immune system because of the cross-targeting of these infections. Thus I am suggesting this is why the baby is born with autism.
Frontal lobe and maternal antibody caused autism
http://www.ncbi.nlm.nih.gov/pubmed/23395715
http://www.ncbi.nlm.nih.gov/pubmed/22911883
Maternal antibodies caused monkey's brains to grow abnormal in the frontal lobe
http://www.ncbi.nlm.nih.gov/pubmed/23838889
Rheumatoid arthritis, autism, and maternal antibodies
http://sfari.org/news-and-opinion/news/2013/large-study-links-autism-to-autoimmune-disease-in-mothers
Flu during pregnancy increase autism
http://www.webmd.com/brain/autism/news/20121109/flu-pregnancy-autism
Flu virus if it has access to the brain infects the frontal lobe
http://www.ncbi.nlm.nih.gov/pubmed/10788752
http://www.ncbi.nlm.nih.gov/pubmed/17094568
These children would be born autistic. They would not be the recessive kind of autism seen in previous posts. They are not vaccine triggered. The area of the brain attacked by the immune system is different thus these autism should have some symptoms that are different.
my posts of RA as a cross-targeting autoimmune disease in adults
http://angelabiggs.blogspot.com/2014/11/autoimmune-cross-targeting-could-cause.html
my posts of Autism as the recessive forms:
the cerebellum form involving ataxia
http://angelabiggs.blogspot.com/2015/02/mmr-vaccine-overlapping-with-sutterella.html
the temporal lobe form involving hearing issues
http://angelabiggs.blogspot.com/2015/02/dtp-vaccine-reactions-and-6th-disease.html
These are different from the autism we are looking at here.
Autism and seizures have been seen together
http://www.ncbi.nlm.nih.gov/pubmed/25599987
http://www.ncbi.nlm.nih.gov/pubmed/16932856
http://www.ncbi.nlm.nih.gov/pubmed/15791919
This last reference is important in that it states the the regressive form of autism does not have the comorbidity with epilepsy?
The flu virus does infect the basal ganglia.
(But here it sounds like the MMR/sutterella autism might have seizures
http://www.ncbi.nlm.nih.gov/pubmed/18766162
http://www.ncbi.nlm.nih.gov/pubmed/23666039
this must be due to the connections of the cerebellum and hypothalamus
http://www.ncbi.nlm.nih.gov/pubmed/2644872)
Are the seizures in this case of immediate autism are from the RA and it's effect on the hypothalamus
http://www.clinexprheumatol.org/article.asp?a=2652
Lupus in children and the presence of seizures
http://www.ncbi.nlm.nih.gov/pubmed/8554655
Adults with lupus complications including seizures
http://www.ncbi.nlm.nih.gov/pubmed/18537650
Absent seizure with MG and lupus in a child
(mycoplasmas with polio/enterovirus)
http://www.ncbi.nlm.nih.gov/pubmed/9294315
http://www.ncbi.nlm.nih.gov/pubmed/4999164
http://www.ncbi.nlm.nih.gov/pubmed/5483199
http://www.ncbi.nlm.nih.gov/pubmed/5433055
Rheumatoid arthritis, mycoplasmas, and seizures
http://www.ncbi.nlm.nih.gov/pubmed/17690887
http://www.ncbi.nlm.nih.gov/pubmed/19049505
http://www.ncbi.nlm.nih.gov/pubmed/15066670 (anti cardio lipin)
cardiolipin antibodies and RA
http://www.ncbi.nlm.nih.gov/pubmed/3664159
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