Tuesday, February 24, 2015

Cross-targeting of the brain and spinal causes autoimmunity

The basal ganglia is involved for Tourettes but it is not an autoimmune but a genetic disease.
The gene involves changes of histamine production in the basal ganglia
http://www.medicalnewstoday.com/articles/271058.php
Could this be triggered by allergies? Tourettes is no longer viewed as autoimmune on this blog. Pandas which is similar in symptoms I do consider as autoimmune.

This is an Autoimmune hypothesis blog.

Hypothesis:
The cross-targeting of  2 infections on one target triggers autoimmunity.  A virus marks the inside and a bacteria, mycobacteria or larger type of infection marks the outside. The target is clearly important in determining which autoimmune disease develops. Note that the larger infection which breaks the blood brain barrier creates the hole letting the virus in behind it.  Then they infect their target.

This page is an over view and a contemplation while the rest of this blog has reference links.

Basal ganglia autoimmunity: Pandas (tourettes like)
Herpes Simplex hhv1 or flu virus / mycobacteria or strep

 The herpes viruses wax and wane out of latency which could explain the coming and going of symptoms.  Note that OCD has been found in some Alzheimer's patients which would be in the herpes group because the herpes virus infects the mitochondria of cells.  Alzheimer's is a disease of mitochondrias no longer functioning.

Hypocretin neurons autoimmunity: narcolepsy
swine flu H1N1 / strep
http://www.ima.org.il/FilesUpload/IMAJ/0/95/47598.pdf
http://healthysleep.med.harvard.edu/narcolepsy/what-is-narcolepsy/science-of-narcolepsy

Periphery nerves autoimmunity: Guilian barre syndrome
Epstein barr (hhv4) or flaviviruses or flu ? / Campylobacteria Jejuni/ sutterella or mycoplasmas

Substantia Nigra autoimmunity: Parkinson's
avian flu H5N1 / mycobacteria (psoriasis connected )

Amygdala autoimmunity :schizophrenia
t.gondii or mycobacteria / herpes simplex virus or epstein barr? (hhv1or hhv4)

link showing schizophrenia and amygdala connection
http://ajp.psychiatryonline.org/doi/abs/10.1176/appi.ajp.2008.08020261

Hypothalamus autoimmunity : seizures
t.gondii / enteroviruses
note that nodding disease might fall here too

Temporal lobe autoimmunity: Autism after dtp
enteroviruses or herpes 6 (hhv6) / tetanus

Frontal lobe autoimmunity: born with Autism
flu virus / mycoplasmas (rheumatoid arthritis)

Cerebellum autoimmunity: Autsim after MMR
Measles virus/ sutterella bacteria

interesting personal post about pick's and autism
http://www.healthboards.com/boards/autism-spectrum/409658-autism-frontal-lobe-dementia.html

Anterior horn cells of the spinal cord autoimmunity:  ALS
enterovirus like polio/ Trichophyton at the nerve endings? (it does make us itch)
note that at least 10% of ALS is a genetic not the infectious cause and the gene  C9orf72
What this gene does is currently unknown but it probably involves nerve endings.

post polio syndrome and als
http://postpolio.ofoonr.lublin.pl/PPS-conf/Abstract_PPS.ALS_en.pdf

Anterior horn cells autoimmunity : paralysis kids of denver
d68 enterovirus and staph from asthma/eczema
(anterior horn cells are in the spinal cord)

Autoimmunity of nerves : Multiple sclerosis
herpes zoster hhv3/ psoriasis mycobacterias or eczema staph

There are 3 different types of autism covered by this blog and they involve different areas of the brain.

Cerebellum: MMR and sutterella
Temporal lobe: DTP and 6th disease (herpes 6)
Frontal lobe: mother's RA autoimmunity  producing antibodies attacking brain and then the mothers catch the flu

All of the large infections that cross the blood brain barrier can or will be associated with gluten sensitivity: strep, t.gondii, e.coli, candida, sutterella, and mycobacterias.

Barrier crossing infections cross both the intestine and the blood brain barrier.  When they cross the intestine however they do not cause celiac disease.  E.coli infects the intestine itself and when cross targeted with a stomach virus triggers the autoimmune disease celiac disease.  Celiac patients tend to have a history of bladder infections in addition to gluten sensitivity. Or at least that is the prediction of my hypothesis.







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