Wednesday, February 18, 2015

Kikuchi-Fujimoto disease is this caused by autoimmune cross-targeting?

Hypothesis: Autoimmune disease is triggered when 2 infections cross-target on one cell type.  A virus hhv-6 marks in the inside and an infection like aspergillus marks the outside which in Kikuchi-Fujimoto disease is the lymph node cells.

Kikuchi-Fujimoto disease is an autoimmune disease of the lymph nodes
http://www.ncbi.nlm.nih.gov/pubmed/25574175
http://www.ncbi.nlm.nih.gov/pubmed/20121621
Most common in asia

Which viruses infect the lymph nodes and are associated with Kikuchi?
Note that it can be any one of these with the outer infection

hhv-8
http://www.medicinenet.com/script/main/art.asp?articlekey=11476
hhv-8 infects the lymph node
http://www.ncbi.nlm.nih.gov/pubmed/15832089

hhv-6
http://www.ncbi.nlm.nih.gov/pubmed/12659352
infects the lymph node and can cause mono like symptoms
http://hhv-6foundation.org/associated-conditions/hhv-6-mononucleosis-lymphadenopathy

EBV
http://www.ncbi.nlm.nih.gov/pubmed/18787614
causes mono....infects the lymph nodes

Parvovirus
http://www.ncbi.nlm.nih.gov/pubmed/22939574
note that parvovirus infects the lymph nodes
http://www.ncbi.nlm.nih.gov/pubmed/8136290

Which outer infection is involved?

Sjogren's, lupus, and kikuchi seem to be connected.
http://www.ncbi.nlm.nih.gov/pubmed/16465479
http://link.springer.com/article/10.1007%2Fs10067-005-0184-z?LI=true
http://www.ncbi.nlm.nih.gov/pubmed/12928530
http://www.ncbi.nlm.nih.gov/pubmed/20082108
http://www.ncbi.nlm.nih.gov/pubmed/21713349
http://www.ncbi.nlm.nih.gov/pubmed/18465190

Earlier posts I had associated sjogren's with candida like infections.

Is Kikuchi-Fugimoto a fungal infection in the lymph node cross-targeting with one of these viruses?
What fungal infection of Japan is this?

Most sinus fungal infections in Japan are Aspergillus
http://www.hindawi.com/journals/ijoto/2013/731640/

Aspergillus oryzae in Japan is common
http://www.nature.com/nature/journal/v438/n7071/abs/nature04300.html
A. oryzae is used for making miso, soy sauce, and sake in Japan and workers have been inhaling them.

vitiligo and sjogren's in japan
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2715204/
is this connected????

This autoimmune disease will continue to be analyzed and updated because the connections are weak.







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