Sunday, February 15, 2015

Does Cross-targeting autoimmunity cause Febrile seizures after the pertussis vaccine?

Does pertussis cause seizures by an autoimmune-cross targeting similar to t.gondii because it infects the hypothalamus?  do the pieces of vaccine although unable to cause whooping cough still migrate to and cause autoimmunity at the hypothalamus?

Autoimmune cross-targeting hypothesis: a virus marks the inside of a cell while an infection marks the outside and the combination triggers autoimmune disease.

Is this pertussis reaction like the t.gondii and the black fly parasite? Does pertussis overlap with an enterovirus causing autoimmune seizures? (previous posts looked at t.gondii and such parasites connections to seizures)

Febrile seizures after pertussis vaccine
http://jama.jamanetwork.com/article.aspx?articleid=1355993
http://www.ncbi.nlm.nih.gov/pubmed/22368426

Evidence of enteroviruses in Febrile seizures
http://www.ncbi.nlm.nih.gov/pubmed/9041348
http://www.ncbi.nlm.nih.gov/pubmed/11134476

Hypothalamus involvement with pertussis
http://www.ncbi.nlm.nih.gov/pubmed/13921428

The connection of the hypothalamus to seizures has been investigated.
http://emedicine.medscape.com/article/1186872-overview

(remember that t.gondii infections involve the amygdala and hypothalamus and that schizophrenia has high rates of seizures but it is unclear if infants have infections)

Previous post which looked at nodding disease and seizures:
http://angelabiggs.blogspot.com/2015/01/nodding-disease-epilepsy-seizuresare.html


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