Tuesday, January 27, 2015

Nodding disease, epilepsy, seizures....are they from autoimmune cross-targeting? a parasite with an enterovirus?

Autoimmune cross-targeting hypothesis: a virus marks the inside of a cell while an infection marks the outside and the combination triggers autoimmune disease.

If we say these diseases are autoimmune can we find the 2 infections for each:

nodding disease: Trypanosoma brucei and polio or live polio vaccine (an enterovirus)

epilepsy: t.gondii or t.cruzi or malaria and enteroviruses

RA seizures: polio/enterovirus and  mycoplasmas?

Description of nodding disease
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3646179/

Trypanosoma brucei a parasite of the black fly infects kids with the african nodding disease
http://workforce.calu.edu/Buckelew/Trypanosoma%20brucei%20rhodesiense%20brain%20section.htm   or is it the worm O.volvulus?

 trypanosome in the nervous system with spinal lesions
http://www.veterinaryresearch.org/content/42/1/63

The trypanosoma parasite can also effect the hypothalamus
http://www.ncbi.nlm.nih.gov/pubmed/15304634

Onchocerca volvulus and epilepsy ? is this the mild form of cross-targeting with an enterovirus whereas the trypanosome causes the nodding disease?
http://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.0002147

Polio, live polio vaccines and the African nodding disease? Are they causing cross-targeting triggering the nodding disease ? Is nodding disease autoimmune?  Enteroviruses infect and replicate in the hypothalamus.

Can we look for similar patterns with the parasite t.gondii?

schizophrenia and the hypothalamus
http://www.ncbi.nlm.nih.gov/pubmed/20923924

Schizophrenia and epilepsy
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2768382/

T.Gondi and epilepsy
http://www.ncbi.nlm.nih.gov/pubmed/2479399

Cats with t.gondi and seizures
http://www.ncbi.nlm.nih.gov/pubmed/15914056

schizophrenia and febrile seizures
http://www.ncbi.nlm.nih.gov/pubmed/15653280

toxocariasis and epilepsy
http://www.ncbi.nlm.nih.gov/pubmed/22905274

Autoimmune epilepsy and anti-nmda receptor
http://www.annalsofian.org/article.asp?issn=0972-2327;year=2013;volume=16;issue=4;spage=577;epage=584;aulast=Pandit

anti-nmda receptor antibodies in pediatric epilepsy
http://www.ncbi.nlm.nih.gov/pubmed/25625089
http://www.ncbi.nlm.nih.gov/pubmed/24656207

They can't find the parasite in the babies. Perhaps the mother was the infected one? Here we do have a direct connection to enteroviruses.

Schizophernia and NMDA
http://www.ncbi.nlm.nih.gov/pubmed/25069261

T.cruzi (chagas) and seizures
http://www.ncbi.nlm.nih.gov/pubmed/6789802
http://www.ncbi.nlm.nih.gov/pubmed/19859889

malaria and seizures...and enteroviruses
http://www.ncbi.nlm.nih.gov/pubmed/8761576
http://www.ncbi.nlm.nih.gov/pubmed/15117128
http://www.ncbi.nlm.nih.gov/pubmed/?term=malaria+seizures+enterovirus
http://www.ncbi.nlm.nih.gov/pubmed/25423900

What I am thinking: around 20% of the population has t.gondii but 20% do not have schizophrenia and 20% of babies do not have seizures so autoimmune cross-targeting might be occurring to set things off.  In the case of seizures...an enterovirus.

Absent seizure with MG and lupus in a child
(mycoplasmas with polio/enterovirus)
http://www.ncbi.nlm.nih.gov/pubmed/9294315
http://www.ncbi.nlm.nih.gov/pubmed/4999164
http://www.ncbi.nlm.nih.gov/pubmed/5483199
http://www.ncbi.nlm.nih.gov/pubmed/5433055

Rheumatoid arthritis, mycoplasmas, and seizures
http://www.ncbi.nlm.nih.gov/pubmed/17690887
http://www.ncbi.nlm.nih.gov/pubmed/19049505
http://www.ncbi.nlm.nih.gov/pubmed/15066670 (anti cardio lipin)
cardiolipin antibodies and RA
http://www.ncbi.nlm.nih.gov/pubmed/3664159



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