Monday, January 26, 2015

Is Myasthenia gravis an autoimmune disease caused by the cross-targeting of mycoplasmas and a virus that infects the thymus?? are there more cases of MG after D68 ?

Autoimmune cross-targeting hypothesis: that the layering of 2 infections on one target confuses the immune system into autoimmune attack. A virus marking the inside of the thymus and an infection like mycoplasmas marking the outside for myasthenia gravis

polio virus and thymus
http://www.ncbi.nlm.nih.gov/pubmed/20368632

the d68 is a similar enterovirus...does it infect the thymus?

They were looking at enteroviruses as a diabetes trigger with a thymus connection for a while.
http://brainimmune.tumblr.com/post/65440027379/an-enterovirus-attacking-the-thymus-may-play-a-key but i believe only coxsackie has been connected.  I think it is the only enterovirus that infects the pancreas

this MG looked like the post-polio syndrome...but was it a real overlap by the virus?
http://www.ncbi.nlm.nih.gov/pubmed/16546772

epstein-barr and thymus???
http://www.ncbi.nlm.nih.gov/pubmed/20517934


Mycoplasmas and viruses in MG???
http://www.ncbi.nlm.nih.gov/pubmed/689042
they didn't see any

Families will have MG and/or RA
http://archinte.jamanetwork.com/article.aspx?articleid=576834


Extra stuff: 
What is rippling muscle disease? Here it is seen overlapping MG
http://www.ncbi.nlm.nih.gov/pubmed/25534474

acquired rippling muscle disease is autoimmune
http://www.ncbi.nlm.nih.gov/pubmed/21295981
http://www.ncbi.nlm.nih.gov/pubmed/8639072

antibodies in rippling muscle..any clues to a virus? the antibodies are to muscles
http://www.ncbi.nlm.nih.gov/pubmed/10529381

Here are some enteroviruses in muscle biopsies
http://ard.bmj.com/content/49/5/310.short

not the enterovirus we are looking at but related
http://www.pnas.org/content/89/1/314.short

High number of MG have antibodies against muscles
http://www.ncbi.nlm.nih.gov/pubmed/22882218

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