Tuesday, July 28, 2015

Is the dengue autoimmune reaction caused by cross-targeting?

Autoimmune cross-targeting hypothesis: a virus marks the inside of a cell while a larger infection marks the outside and the combination triggers autoimmune disease.  The immune system is instructed to destroy both the inside and the outside of the target.

Dengue virus and autoimmune disease reaction:  hemorrhagic fever or shock syndrome
http://www.ncbi.nlm.nih.gov/pubmed/16817755

Dengue is in the family of viruses Flaviviridae  like west nile and yellow fever
25% of cases become autoimmune
http://www.virologyj.com/content/6/1/211

the dengue virus and yellow fever virus infects dendritic cells
http://www.ncbi.nlm.nih.gov/pubmed/21894381

west nile and dendritic cells
http://www.jimmunol.org/content/194/1_Supplement/54.27

when they looked for viruses in their dendritic cells they found mycoplasma contamination
http://www.sciencedirect.com/science/article/pii/S016524780700079X

Dendritic cells are already known to be a target in Rheumatic disease
http://www.ncbi.nlm.nih.gov/pubmed/19405176

I have previously already linked mycoplasmas with rheumatic disease

Could mycoplasmas coat the outside of dendritic cells? Are the people who have the severe reaction to dengue infected with mycoplasmas?



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