Monday, July 6, 2015

Do herpes viruses use estrogen receptors to infect cells?

Herpes viruses infects the mitochondria of nerves and estrogen organs.  It is now know that nerves have a special beta-estrogen receptor which cycles to the the mitochondria of nerves. Does this explain why the hereps virus can hide in the the mitochondria of nerves?

estrogen and herpes
http://www.ncbi.nlm.nih.gov/pubmed/19846508
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2798450/

estrogen receptor-beta is relocated to the mitochondria
http://www.pnas.org/content/101/12/4130.full.pdf
http://www.jbc.org/content/284/14/9540.full

estrogen receptor-beta is primarily in the CNS
http://www.ncbi.nlm.nih.gov/pubmed/9419830

reactivation of herpes is estrogen receptor dependent
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2798450/

https://books.google.com/books?id=6hU_rtHBxLsC&pg=PT81&lpg=PT81&dq=estrogen+herpes+receptor&source=bl&ots=77CxPhSUdL&sig=9qXhgZuljNlO_XY1UhjC7ng_ClE&hl=en&sa=X&ei=uB-LVZyBJ8fYoASImrfwAg&ved=0CEcQ6AEwBQ#v=onepage&q=estrogen%20herpes%20receptor&f=false

Does the herpes virus use the estrogen receptor?
it does infect estrogen receptor organs not just nerves...yes
http://link.springer.com/article/10.1007%2FBF01310768#page-1

mitochondria, estrogen, and nerves
http://pharmweb.usc.edu/brinton-lab/documents/2004/NilsenJ_CurDrugTarg3_2004.pdf

Other things to consider:

Herpes uses multiple things including TNF receptor is this similar to the estrogen receptor?
http://www.ncbi.nlm.nih.gov/pubmed/15056211

TNF alpha activation causes the "release of mitochondria"
http://www.nature.com/cddis/journal/v5/n7/full/cddis2014277a.html


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