Friday, July 31, 2015

Do flaviviruses infect using Melanocortin Receptors ?

Do flaviviruses infect using melanocortin receptors ? I ask based on infection patterns.

Melancortin receptors are in the kidney and the nervous system
http://www.alomone.com/Article.aspx?Item=1186

West nile and kidney disease
http://www.medpagetoday.com/MeetingCoverage/NKF/38283

Dengue and kidney disease
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3999585/
http://www.ncbi.nlm.nih.gov/pubmed/24772398

Yellow fever
obviously this infects the liver making one look yellow but does it infect the kidney?
http://www.ncbi.nlm.nih.gov/pubmed/23648410  is the virus in the kidney?

There are melancortin receptors in the liver but according to this most are in the brain
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3312751/

ACTH specifically is a melancortin receptor
https://en.wikipedia.org/wiki/ACTH_receptor

The main areas of melancortin receptors include the substantia nigra (so this virus could trigger parkinson's)
https://books.google.com/books?id=gR73BwAAQBAJ&pg=PA129&lpg=PA129&dq=substantia+nigra+melanocortin+receptors&source=bl&ots=yCqWD0krtK&sig=d5HR54afH7VxwpXImCt00Ry-UW0&hl=en&sa=X&ved=0CDMQ6AEwAmoVChMIr8DCqsaFxwIVURWSCh0fVQKF#v=onepage&q=substantia%20nigra%20melanocortin%20receptors&f=false


Melancortin receptors are on prostate cells
http://www.ncbi.nlm.nih.gov/pubmed/22842514

Melancortin receptors are in the skin meloanocytes
http://www.ncbi.nlm.nih.gov/pubmed/26197705




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