Wednesday, March 1, 2017

Retroviruses seem to be using LH receptors or Albumin binding receptors

Retroviruses seem to be using LH receptor or albumin binding receptors.

 Retroviruses include the bovine leukemia virus and the human t-cell leukemia virus (BLV and HTLV).  I know that CD4 is suppose to be the receptor but....looking at the patterns I would guess LH receptors for these.

 The feline leukemia virus and the Rous sarcoma virus are related but seem to bind albumin binding receptors.

Albumin and LH antibody cross-reaction
https://www.ncbi.nlm.nih.gov/pubmed/2102467
(there must be a common antigen which could be what binds the receptors)

HLA-DR5 seems linked to Retroviruses
note that HLA-DR12 which is similar to HLA-DR5 binds Paramyxoviruses (measles)

I divided the receptors up into positive and negative
http://angelabiggs.blogspot.com/2016/12/viruses-and-benzene-rings.html

Charged molecules are drawn to the receptors and the virus must being do this too with a similar amino acid key. I am not sure which group these retroviruses are.

Na ions alter the ability of  LH to bind the LH receptor 
https://www.ncbi.nlm.nih.gov/labs/articles/8395653/

LH is a transmembrane receptor
https://en.wikipedia.org/wiki/Luteinizing_hormone/choriogonadotropin_receptor

LH and Treg
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4083450/

Treg and HIV
https://www.ncbi.nlm.nih.gov/m/pubmed/23043072/

Treg and HIV
http://www.nature.com/articles/ncomms9608

LH holds Tcell at Treg, LH receptors cause the immune suppression (of pregnancy)
https://www.ncbi.nlm.nih.gov/m/pubmed/24592927/

LH receptor and preclampsia
https://www.ncbi.nlm.nih.gov/pubmed/25676660

hCG is a hormone produced by the placenta to suppress the immune system during pregnancy (and acts on the LH receptor)

the TM protein of retroviruses like the TM of HIV seems to be involved in this suppression
TM is transmembrane protein
https://www.ncbi.nlm.nih.gov/m/pubmed/24592927/

Bovine leukemia virus and breast cancer??? is this the vascular kind???
http://news.berkeley.edu/2015/09/15/bovine-leukemia-virus-breast-cancer/

LH receptors, gonads and vascular tissue
http://www.ncbi.nlm.nih.gov/pubmed/14666164

feline leukemia virus and thiamine transporter
https://www.ncbi.nlm.nih.gov/pubmed/16537605
https://www.fredhutch.org/en/news/spotlight/imports/feline-leukemia-virus-inhibits-thiamine-uptake--with-pathologica.html

Albumin and LH antibody cross-reaction
https://www.ncbi.nlm.nih.gov/pubmed/2102467

thiamine binds albumin in the blood....does the transporter bind albumin?

Rous sarcoma virus and lipoprotein receptor
http://www.cell.com/abstract/0092-8674(93)90726-7

lipoproteins are carried by albumin

albumin is very negatively charged so the receptor binding must be positive with a sodium

mouse mammary tumor virus and mouse transferrin receptor
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2641025/

Transferrin receptors and albumin
https://www.ncbi.nlm.nih.gov/pubmed/3415986
(looks like albumin displaced the transferrin)




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