Thursday, March 23, 2017

Polyomaviruses and their receptors: serotonin and gangliosides at the ER and not the VDR????

Polyomaviruses go through the Endoplasmic reticulum before getting to the nucleus.  Polyomaviruses cause cancer so we know they get to the nucleus and we know they pass through the ER because the viruses have both been found there and trigger HLA-C.

The receptors polyomaviruses use must therefore travel through the ER.

JC and serotonin receptors
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3838264/
https://www.ncbi.nlm.nih.gov/pubmed/15550673

Serotonin receptors localized at the smooth endoplasmic reticulum
http://www.sciencedirect.com/science/article/pii/S000689930002062X

Bk and ganglioside receptors which pass through the Endoplasmic reticulum
https://experts.umich.edu/en/publications/identification-of-gangliosides-gd1b-and-gt1b-as-receptors-for-bk-

Gangliosides and sv40 virus
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC202381/

serotonin was once considered an ganglioside?

Both serotonin and gangliosides are stored in the smooth ER

antibodies overlap for serotonin and gangliosides
http://www.sciencedirect.com/science/article/pii/0306453092900172





1 comment: