Francis Peyton Rous' Co-carcinogenesis hypothesis: that a virus and a carcinogen together cause cancer. (1966 Nobel prize for HPV work) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2135410/
My co-carcinogenesis takes his further because carcinogens inhibit polymerases.
What I surmise from his hypothesis:
Cancer occurs because a carcinogen inhibits the viral polymerase better than the human polymerase. When a virus infects the same cell as a carcinogen they interact. Instead of the virus making what it wants in the host the infected cell is transformed into a cancer cell by the carcinogen.
what causes melanoma? a virus demethylating the DNA or the sun?
Sun exposure and demethylation
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2877750/
melanoma and herv-K
https://www.ncbi.nlm.nih.gov/pubmed/23311654
demethylation and melanoma
http://cancerdiscovery.aacrjournals.org/content/5/8/OF6
http://www.sciencedirect.com/science/article/pii/S0014579315010248
https://www.scholars.northwestern.edu/en/publications/clinically-relevant-genes-and-regulatory-pathways-associated-with
melanocortin receptor 1 and melanoma
https://www.ncbi.nlm.nih.gov/pubmed/24460937
https://www.ncbi.nlm.nih.gov/pubmed/25017567
prostate cancer increased risk melanoma
http://www.medscape.com/viewarticle/813922
Hepatitis C (a flavivirus) and prostate cancer
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1677-55382011000200009
Melanoma 4x higher in parkinon's patients
http://www.medscape.com/viewarticle/806837
Hepatitis C and parkinson's disease risk
https://www.ncbi.nlm.nih.gov/pubmed/25608223
However patients with Hep C appear to have a DECREASED risk of melanoma in sweden
https://www.ncbi.nlm.nih.gov/pubmed/28374973
non epithelial skin cancer does increase with Hep C ?
http://www.oncologynurseadvisor.com/gastrointestinal-cancer/hepatocellular-carcinoma-hepatitis-c-virus-higher-risk-cancers/article/633949/
Lipocalin protein and melanoma
http://www.ncbi.nlm.nih.gov/pubmed/22299829
Lipocalin and West Nile virus
http://www.ncbi.nlm.nih.gov/pubmed/24173226
West nile uses MCR3
Could a different flavivirus use the melanocortin receptor one which would explain the overlap of prostate cancer and parkinson's disease with melanoma? What is going on?????
My co-carcinogenesis takes his further because carcinogens inhibit polymerases.
Cancer occurs because a carcinogen inhibits the viral polymerase better than the human polymerase. When a virus infects the same cell as a carcinogen they interact. Instead of the virus making what it wants in the host the infected cell is transformed into a cancer cell by the carcinogen.
what causes melanoma? a virus demethylating the DNA or the sun?
Sun exposure and demethylation
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2877750/
melanoma and herv-K
https://www.ncbi.nlm.nih.gov/pubmed/23311654
demethylation and melanoma
http://cancerdiscovery.aacrjournals.org/content/5/8/OF6
http://www.sciencedirect.com/science/article/pii/S0014579315010248
https://www.scholars.northwestern.edu/en/publications/clinically-relevant-genes-and-regulatory-pathways-associated-with
melanocortin receptor 1 and melanoma
https://www.ncbi.nlm.nih.gov/pubmed/24460937
https://www.ncbi.nlm.nih.gov/pubmed/25017567
prostate cancer increased risk melanoma
http://www.medscape.com/viewarticle/813922
Hepatitis C (a flavivirus) and prostate cancer
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1677-55382011000200009
Melanoma 4x higher in parkinon's patients
http://www.medscape.com/viewarticle/806837
Hepatitis C and parkinson's disease risk
https://www.ncbi.nlm.nih.gov/pubmed/25608223
However patients with Hep C appear to have a DECREASED risk of melanoma in sweden
https://www.ncbi.nlm.nih.gov/pubmed/28374973
non epithelial skin cancer does increase with Hep C ?
http://www.oncologynurseadvisor.com/gastrointestinal-cancer/hepatocellular-carcinoma-hepatitis-c-virus-higher-risk-cancers/article/633949/
Lipocalin protein and melanoma
http://www.ncbi.nlm.nih.gov/pubmed/22299829
Lipocalin and West Nile virus
http://www.ncbi.nlm.nih.gov/pubmed/24173226
West nile uses MCR3
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