Ovarian cancer has been linked to HPV and CMV but not HIV. If HIV uses LH receptors they would infect ovarian cells.
Theca externa contain spindle stromal cells while the theca internal lutein cells do the hormonal secretions. All of these cells have LH receptors.
Oocytes are surrounded by granulose cells then theca cells....when ovulation occurs LH levels drop but don't LH levels don't end until it is obvious that fertilization has not occurred.
LH encourages the CLM (corpus luteum of menstration which is the collapsed follicle) to make progesterone and estrogen. (the theca cells have the LH receptors)
Oddly HIV does not cause ovarian cancer. Why not?
HIV looks like it causes premature menopause
https://www.ncbi.nlm.nih.gov/pubmed/24303653
LH receptor induces apoptosis if triggered alone
https://www.ncbi.nlm.nih.gov/pubmed/21711548
So if the HIV virus infects these cells using LH receptors they immediate commit suicide? Hence the death of ovarian cells.
Hamster theca cells have smooth muscle actin (just thinking about the spindle structure)
https://academic.oup.com/biolreprod/article/2763548/Hamster
Extra thoughts:
The HPV would cause demethylation which is the herv K route and the more aggressive cancer.
Ovarian cancer and herv-k
https://www.ncbi.nlm.nih.gov/pubmed/17013901
While the hypermethylation group of ovarian and breast cancer involves the BRCA gene (about 14%)
https://www.ncbi.nlm.nih.gov/pubmed/24889916
could hypermethylation would be caused by the herpes form of ovarian cancer or is it HPV suppressing the BRCA inihibition?
What is BRCA? These are genes that alter a cancer cell's apoptosis (suicide pathway).
https://link.springer.com/article/10.1007/s11433-011-4264-6
If these genes are turned on by hypermethylation and you are the carrier for the version of the gene that favors cancer cell "rescue" then this form cancer tends to be larger than otherwise seen and can escape the immune system through numbers.
Theca externa contain spindle stromal cells while the theca internal lutein cells do the hormonal secretions. All of these cells have LH receptors.
Oocytes are surrounded by granulose cells then theca cells....when ovulation occurs LH levels drop but don't LH levels don't end until it is obvious that fertilization has not occurred.
LH encourages the CLM (corpus luteum of menstration which is the collapsed follicle) to make progesterone and estrogen. (the theca cells have the LH receptors)
Oddly HIV does not cause ovarian cancer. Why not?
HIV looks like it causes premature menopause
https://www.ncbi.nlm.nih.gov/pubmed/24303653
LH receptor induces apoptosis if triggered alone
https://www.ncbi.nlm.nih.gov/pubmed/21711548
So if the HIV virus infects these cells using LH receptors they immediate commit suicide? Hence the death of ovarian cells.
Hamster theca cells have smooth muscle actin (just thinking about the spindle structure)
https://academic.oup.com/biolreprod/article/2763548/Hamster
Extra thoughts:
The HPV would cause demethylation which is the herv K route and the more aggressive cancer.
Ovarian cancer and herv-k
https://www.ncbi.nlm.nih.gov/pubmed/17013901
While the hypermethylation group of ovarian and breast cancer involves the BRCA gene (about 14%)
https://www.ncbi.nlm.nih.gov/pubmed/24889916
could hypermethylation would be caused by the herpes form of ovarian cancer or is it HPV suppressing the BRCA inihibition?
What is BRCA? These are genes that alter a cancer cell's apoptosis (suicide pathway).
https://link.springer.com/article/10.1007/s11433-011-4264-6
If these genes are turned on by hypermethylation and you are the carrier for the version of the gene that favors cancer cell "rescue" then this form cancer tends to be larger than otherwise seen and can escape the immune system through numbers.
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