Thursday, March 30, 2017

VDR and the immune system : Does the liver turn immune responses off with vit D?

Activated immune system cells have VDR receptors

T cells and VDR
https://www.ncbi.nlm.nih.gov/pubmed/6313738/

B cells and VDR
https://www.ncbi.nlm.nih.gov/pubmed/24761763

APC and VDR (antigen presenting cells)
https://www.hindawi.com/journals/jir/2013/807971/

Macrophages activated have VDR expression triggered by TLR
https://www.ncbi.nlm.nih.gov/pubmed/16497887

APC are inhibited by vit D.  Is VDR the off switch for the immune system?

Is this why Vit D deficiency can be linked to higher rates of autoimmunity where the immune system hasn't stopped and functions out of control against self.

It has been suggested that the liver is an immunological organ
http://onlinelibrary.wiley.com/store/10.1002/hep.21060/asset/21060_ftp.pdf?v=1&t=j0wh4jbd&s=37e136ec8613f8ca7419382797c53418751a12d7

Vit D is fat soluble and cod liver oil which is high in omega fats is also high in Vit D.
(tempted to say omega fats carry the vit D)













No comments:

Post a Comment