Bone cancers, viruses, and methylation

Bone cancers (not including lymphoma or leukemia)

Francis Peyton Rous' Co-carcinogenesis hypothesis: that a virus and a carcinogen together cause cancer. (1966 Nobel prize for HPV work)  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2135410/

My co-carcinogenesis takes his further because carcinogens inhibit polymerases.

What I surmise from his hypothesis:

Cancer occurs because a carcinogen inhibits the viral polymerase better than the human polymerase. When a virus infects the same cell as a carcinogen they interact.  Instead of the virus making what it wants in the host the infected cell is transformed into a cancer cell by the carcinogen. 

Under 20

Retrovirus       Osteosarcoma
Herpes virus   Ewings sarcoma

Over 50

Retrovirus       spindle sarcoma
Herpes virus     Chondrosarcoma

between 20-50 you see an overlap of these cancers

Any age

Polyomavirus   Chordoma


Note that Herpes viruses (CMV or EBV) and polyomaviruses use DNA methylation which awakens Herv H and Herv W and these are considered slow growing cancers.

The Retroviruses which use DNA demethylation awaken Herv K and Herv E and are considered fast growing cancers.

Retroviruses and osteosarcoma
https://link.springer.com/chapter/10.1007%2F978-1-4615-3518-8_2#page-1

HIV (retrovirus) and osteosarcoma
https://www.semanticscholar.org/paper/Osteosarcoma-in-Adult-Patients-Living-with-HIV-Marais-Ferreira/d0a7c15fe1654a40d6b3355cab45a165649f7d3f

marine sarcoma virus and osteosarcoma
http://jvi.asm.org/content/26/1/11.full.pdf

demethylation and HIV
http://www.pnas.org/content/112/34/E4762.full

HIV and herv k
https://www.ncbi.nlm.nih.gov/pubmed/24648457

Ewing's and EBV
https://www.ncbi.nlm.nih.gov/pubmed/1659846
https://www.ncbi.nlm.nih.gov/pubmed/12555258

Ewing's and methylation
https://www.ncbi.nlm.nih.gov/pubmed/25202378

Still collecting references