Hypothesis: Virus families bind receptor families
Melanocortin receptors and Flaviviruses (west nile, dengue, zika)
Estrogen receptors (alpha, beta, estrogen-related) and Herpes viruses (alpha, beta, and gamma)
Dopamine receptors and Flu viruses
Acetlycholine receptors and Enteroviruses (d68, coxsackie)
Cannabinoid receptors and Human Papilloma viruses
serotonin receptors and Polyomaviruses (JC virus/sv40, BK, hepatitis B)
luteinizing hormone receptors and retroviruses (rous sarcoma virus, HIV)
Muscarinic receptors and Paramyxoviridae (measles, mumps, RSV, parainfluenza viruses)
Hepatitis A is an enterovirus
Hepatitis B is a polyomavirus
Hepatitis C is a flavivirus
earlier post on receptor binding
collected references
serotonin receptors and polyomaviruses 2012
https://www.ncbi.nlm.nih.gov/pubmed/24089568
herpes reactivation is estrogen receptor dependent 2010
https://www.ncbi.nlm.nih.gov/pubmed/19846508
HHV8 and the estrogen receptor alpha 2008
http://d-scholarship.pitt.edu/8097/
no direct link dopamine and flu but virus always found in dopamine cells
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0051068
The dopamine 2 receptor is on the pancreas
http://www.jbc.org/content/280/44/36824.full
D2 and the substantia nigra
http://www.ncbi.nlm.nih.gov/pubmed/1825842
http://www.hindawi.com/journals/ijmc/2011/403039/
Frontal lobe and D2
http://www.sciencedirect.com/science/article/pii/S1053811906011049
The flu virus and parkinson's
http://news.sciencemag.org/brain-behavior/2009/08/bird-flu-virus-possible-trigger-parkinsons
Could it be that the flu uses the D2 receptor to infect cells?
The receptor that people have found them using is hemaggluten. Hemaggluten is the antigen on red blood cells that we use to identify blood types. This had me puzzled.
However the dopamine D2 receptors have a hemogglutin epitope. ( a matching piece)
http://www.jbc.org/content/274/28/19894.abstract
melatonin protects against flaviviruses
http://www.ncbi.nlm.nih.gov/pubmed/14962057
if you assume virus families use receptor families and look at where flaviviruses infect a possible pattern appears
Flaviviruses look like they bind melanocortin receptors
mcr1 Tick borne encephalitis virus/ hepatitis C (Thrombocytopenia due to red blood cells with mcr1)
mcr2 (ACTH receptor) Zika (placenta, developing brain)
mcr3 West nile (kidneys)
mcr3 and mcr1 Japanese encephalitis
mcr4 Yellow fever (liver)/ hepatitis C (here too)
mcr5 Dengue (immune system T cells) (which explains the second exposure response)
HIV looks like it causes premature menopause
https://www.ncbi.nlm.nih.gov/pubmed/24303653
Menstrual cycle and HIV
https://books.google.com/books?id=cGUEAAAAMBAJ&pg=PA2&lpg=PA2&dq=Luteinizing+hormone+and+HIV&source=bl&ots=wbfbAocMEP&sig=MYmm4wIjsIpThKZQvDe-2rFI27M&hl=en&sa=X&ved=0ahUKEwiFgtKC25zTAhXLrlQKHbUDCG04ChDoAQgjMAQ#v=onepage&q=Luteinizing%20hormone%20and%20HIV&f=false
HIV surges with LH drops so do they use the same receptor?
feline leukemia virus and thiamine transporter
https://www.ncbi.nlm.nih.gov/pubmed/16537605
https://www.fredhutch.org/en/news/spotlight/imports/feline-leukemia-virus-inhibits-thiamine-uptake--with-pathologica.html
LH and albumin antibody cross-reaction
https://www.ncbi.nlm.nih.gov/pubmed/2102467
albumin binds the thiamine transporter and LH receptor...is this what retroviruses bind?
Rabies binds the neurotoxin binding site of the nicotinic acetylcholine receptor
http://www.ncbi.nlm.nih.gov/pubmed/8887475
This neurotoxin binding site is where nicotine binds
http://www.ncbi.nlm.nih.gov/pubmed/3448605
coxsackie virus (an enterovirus) infection is blocked by nicotine
http://www.ncbi.nlm.nih.gov/pubmed/26851533
http://www.ncbi.nlm.nih.gov/pubmed/26507386
http://www.ncbi.nlm.nih.gov/pubmed/26851533
Nectin-like interactions of polio virus binding
http://www.ncbi.nlm.nih.gov/pubmed/25631086
Measles virus binds nectin-4
http://www.ncbi.nlm.nih.gov/pubmed/27483301
since polio virus binds nectins and measles binds nectin 4 is it possible that paramyxoviridae viruses bind muscarinic receptors?
Melanocortin receptors and Flaviviruses (west nile, dengue, zika)
Estrogen receptors (alpha, beta, estrogen-related) and Herpes viruses (alpha, beta, and gamma)
Dopamine receptors and Flu viruses
Acetlycholine receptors and Enteroviruses (d68, coxsackie)
Cannabinoid receptors and Human Papilloma viruses
serotonin receptors and Polyomaviruses (JC virus/sv40, BK, hepatitis B)
luteinizing hormone receptors and retroviruses (rous sarcoma virus, HIV)
Muscarinic receptors and Paramyxoviridae (measles, mumps, RSV, parainfluenza viruses)
NOTES:
Hepatitis A is an enterovirus
Hepatitis B is a polyomavirus
Hepatitis C is a flavivirus
earlier post on receptor binding
receptor hypothesis: positive or negative
serotonin receptors and polyomaviruses 2012
https://www.ncbi.nlm.nih.gov/pubmed/24089568
herpes reactivation is estrogen receptor dependent 2010
https://www.ncbi.nlm.nih.gov/pubmed/19846508
HHV8 and the estrogen receptor alpha 2008
http://d-scholarship.pitt.edu/8097/
no direct link dopamine and flu but virus always found in dopamine cells
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0051068
The dopamine 2 receptor is on the pancreas
http://www.jbc.org/content/280/44/36824.full
D2 and the substantia nigra
http://www.ncbi.nlm.nih.gov/pubmed/1825842
http://www.hindawi.com/journals/ijmc/2011/403039/
Frontal lobe and D2
http://www.sciencedirect.com/science/article/pii/S1053811906011049
The flu virus and parkinson's
http://news.sciencemag.org/brain-behavior/2009/08/bird-flu-virus-possible-trigger-parkinsons
Could it be that the flu uses the D2 receptor to infect cells?
The receptor that people have found them using is hemaggluten. Hemaggluten is the antigen on red blood cells that we use to identify blood types. This had me puzzled.
However the dopamine D2 receptors have a hemogglutin epitope. ( a matching piece)
http://www.jbc.org/content/274/28/19894.abstract
melatonin protects against flaviviruses
http://www.ncbi.nlm.nih.gov/pubmed/14962057
if you assume virus families use receptor families and look at where flaviviruses infect a possible pattern appears
Flaviviruses look like they bind melanocortin receptors
mcr1 Tick borne encephalitis virus/ hepatitis C (Thrombocytopenia due to red blood cells with mcr1)
mcr2 (ACTH receptor) Zika (placenta, developing brain)
mcr3 West nile (kidneys)
mcr3 and mcr1 Japanese encephalitis
mcr4 Yellow fever (liver)/ hepatitis C (here too)
mcr5 Dengue (immune system T cells) (which explains the second exposure response)
HIV looks like it causes premature menopause
https://www.ncbi.nlm.nih.gov/pubmed/24303653
https://books.google.com/books?id=cGUEAAAAMBAJ&pg=PA2&lpg=PA2&dq=Luteinizing+hormone+and+HIV&source=bl&ots=wbfbAocMEP&sig=MYmm4wIjsIpThKZQvDe-2rFI27M&hl=en&sa=X&ved=0ahUKEwiFgtKC25zTAhXLrlQKHbUDCG04ChDoAQgjMAQ#v=onepage&q=Luteinizing%20hormone%20and%20HIV&f=false
HIV surges with LH drops so do they use the same receptor?
feline leukemia virus and thiamine transporter
https://www.ncbi.nlm.nih.gov/pubmed/16537605
https://www.fredhutch.org/en/news/spotlight/imports/feline-leukemia-virus-inhibits-thiamine-uptake--with-pathologica.html
LH and albumin antibody cross-reaction
https://www.ncbi.nlm.nih.gov/pubmed/2102467
albumin binds the thiamine transporter and LH receptor...is this what retroviruses bind?
Rabies binds the neurotoxin binding site of the nicotinic acetylcholine receptor
http://www.ncbi.nlm.nih.gov/pubmed/8887475
This neurotoxin binding site is where nicotine binds
http://www.ncbi.nlm.nih.gov/pubmed/3448605
coxsackie virus (an enterovirus) infection is blocked by nicotine
http://www.ncbi.nlm.nih.gov/pubmed/26851533
http://www.ncbi.nlm.nih.gov/pubmed/26507386
http://www.ncbi.nlm.nih.gov/pubmed/26851533
Nectin-like interactions of polio virus binding
http://www.ncbi.nlm.nih.gov/pubmed/25631086
Measles virus binds nectin-4
http://www.ncbi.nlm.nih.gov/pubmed/27483301
since polio virus binds nectins and measles binds nectin 4 is it possible that paramyxoviridae viruses bind muscarinic receptors?
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