Kidney cancer, viruses, and co-carcinogenesis

Francis Peyton Rous' Co-carcinogenesis hypothesis: that a virus and a carcinogen together cause cancer. (1966 Nobel prize for HPV work)  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2135410/

My co-carcinogenesis takes his further because carcinogens inhibit polymerases.

What I surmise from his hypothesis:

Cancer occurs because a carcinogen inhibits the viral polymerase better than the human polymerase. When a virus infects the same cell as a carcinogen they interact.  Instead of the virus making what it wants in the host the infected cell is transformed into a cancer cell by the carcinogen. 

Smoking carcinogens are the major contributor to Kidney cancer
http://www.cancernetwork.com/renal-cell-carcinoma/smoking-may-increase-risk-death-rcc

4 types of Renal cell carcinoma: clear, papillary, chromophobe, and oncocytoma

Papillary

EBV and Papillary renal cell carcinoma
https://www.ncbi.nlm.nih.gov/labs/articles/17549343/

HHV8 and papillary renal cell carcinoma
https://www.ncbi.nlm.nih.gov/pubmed/24987353

Herpes viruses cause methylation

Methylation and papillary renal cell carcinoma
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4511443/
https://www.ncbi.nlm.nih.gov/pubmed/20553257

looking for herv W from ebv in renal cancer
https://www.ncbi.nlm.nih.gov/pubmed/23028727/

Clear cell

Clear cell renal cell carcinoma and HPV

HPV and renal cell carcinoma
http://onlinelibrary.wiley.com/doi/10.1002/jmv.23945/abstract

clear cell penis carcinoma is squamous HPV
http://journals.lww.com/ajsp/Citation/2016/07000/Clear_Cell_Carcinoma_of_the_Penis___An_HPV_related.6.aspx

HPV does demethylation

Clear cell renal cell carcinoma and herv E
https://www.ncbi.nlm.nih.gov/pubmed/26862115

Clear cell cancer and cannabinoid receptors of the CB1 type are decreased? and CB2 is not expressed?
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2989249/

Here they found over expression of CB1: but they are not specific which kind of RCC
https://www.springermedizin.de/overexpression-of-cannabinoid-receptor-1-promotes-renal-cell-car/10898958

( HPV16 seems to use CB1)

clear cell renal carcinoma actually have a golden yellow appears due to an accumulation of lipids
http://emedicine.medscape.com/article/1612043-overview?pa=58O8ipQc5%2Buu2M08DeBeRLaqlzPm8CfcZzRXra9ztt%2BlokvVNZ%2FAwbhQ5uyMd8txHhCnHvXnShVL70%2Fs9Tn3YrOwhd8Mdk7tVO%2FdkscsGC4%3D

clear cell renal carcinoma seem to lipid issues connect to ceramide levels
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0172632

CB1 cannabinoid receptor one is connected to ceramide
https://www.ncbi.nlm.nih.gov/pubmed/15958274

note that clear cell carcinoma of the cervix is hpv18 which uses the CB2 receptors
http://journals.lww.com/intjgynpathology/Abstract/2012/05000/Clear_Cell_Adenosquamous_Carcinoma_of_the_Cervix__.15.aspx

Papillary thyroid cancer into clear cell renal cancer
https://www.ncbi.nlm.nih.gov/pubmed/28249616

HPV16 and thyroid cancer
https://www.ncbi.nlm.nih.gov/pubmed/18985036

Clear cell of the head and neck connected to metastatic renal cell
http://www.sciencedirect.com/science/article/pii/S1741940904000172

Head and neck cancer with HPV16
https://www.ncbi.nlm.nih.gov/pubmed/24474236


Chromophobe

chromophobe, Birt-hogg-dube, and mitochondrial biogenesis
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4381700/

Chromophobe has increased mitochondrial genesis
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2862395/

Birt-hogg-Dube is a genetic disorder connected to an increase in Mitochondria genesis
https://bmcmedgenomics.biomedcentral.com/articles/10.1186/1755-8794-3-59

Chromophobe and the genetic Birt-hogg-dube have benign hair follicle tumors
https://www.bhdsyndrome.org/wp-content/uploads/2011/03/Vera-Badillo-et-al-2012-Chromophobe-renal-cell-carcinoma-A-review-of-an-uncommon-entity.pdf

the serotonin receptors increases mitochondria biogenesis
http://www.life-enhancement.com/magazine/article/2262-kidney-injury-and-recovery-serotonin-receptor-stimulation-increases-mitochondrial-biogenesis

the polyomavirus may be using serotonin receptors and the BK virus is notorious for infecting kidney transplants
https://www.ncbi.nlm.nih.gov/pubmed/18819837

Oncocytomas are benign tumors with HPV associations (the tumors before a carcinogen?)
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2827107/
https://www.researchgate.net/publication/5687123_High-risk_human_papillomavirus_HPV_in_parotid_lesions

Transitional cell carcinoma

polyomavirus and Transitional ?
https://www.ncbi.nlm.nih.gov/pubmed/23588736
http://onlinelibrary.wiley.com/store/10.1002/dat.20364/asset/20364_ftp.pdf?v=1&t=j1ar62cc&s=c81c67881eabd11a60a3bd544cc86d22fc98599a

Sarcoma

Retroviruses (sarcoma viruses) and kidney cells
https://www.ncbi.nlm.nih.gov/pubmed/1656977

HIV and hepatic spindle cell tumors (kidney spindle cells)
https://www.ncbi.nlm.nih.gov/pubmed/8008509
https://www.ncbi.nlm.nih.gov/pubmed/1656977

Wilms

small unknown virus in wilms
https://www.ncbi.nlm.nih.gov/pubmed/4310023
http://onlinelibrary.wiley.com/doi/10.1002/1097-0142(196909)24:3%3C527::AID-CNCR2820240314%3E3.0.CO%3B2-Z/abstract

hypomethylation
https://www.ncbi.nlm.nih.gov/pubmed/9973957