Viruses open up DNA and either methylate or demethylate it while a carcinogen binds the viral polymerase so the hosts polymerase is free to function....causing cancer.
Does Azathioprine remove the need for a virus or carcinogen? Does the severe breakage of DNA cause Demethylation to the point that Hervs become activated?
Since Azarthioprine involves demethylaltion only those aggressive cancers are seen? Is this true? I am suggesting that it is not just the immunosuppression that causes the cancer but the drug itself.
http://www.cancertherapyadvisor.com/lymphoma/ptld-an-unfortunate-complication-after-transplant/article/268067/
Azathioprine (AZA) is an inhibitor of purine synthesis and has been used as an immunosuppressant since 1960s.[1] Mycophenolate mofetil (MMF) is a more selective inhibitor of purine,
Azathioprine produces high levels of 6TG (which increased skin cancer)
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2426755/
6TG and demethylation
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2430383/
6-thioguanine (6TG), which induces DNA double-strand breaks (DSB) that are repaired
DNA repair stimulates demethylation
http://www.sciencedirect.com/science/article/pii/S0301468108000054
Herv-E and transplants (supports demethylation awakening )
Zygote - demethylation- Blastocyte- methylation- Epiblast (pluripotent cells)
awakens Herv K Herv H
Epiblast -demethylation - PGCs - methylation -Fetus
Herv E Herv W
viruses: HPV/flavivirus Herpes/ polyomaviruses/retroviruses
demethylation methylation
(note that " only nuclear viruses cause cancer" is a current hypothesis)
awakens Herv K Herv H
Epiblast -demethylation - PGCs - methylation -Fetus
Herv E Herv W
viruses: HPV/flavivirus Herpes/ polyomaviruses/retroviruses
demethylation methylation
(note that " only nuclear viruses cause cancer" is a current hypothesis)
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