Serotonin receptors, DNA repair, polyomaviruses, and Osteosarcomas

Osteosarcomas have been shown to be induced by x-rays.  Both polyomaviruses and X-rays have also been linked to papillary thyroid carcinomas.  Both of these cancers have been found to have abnormally high DNA levels.  Interestingly serotonin has been shown to have a protective effect against X-rays and that Serotonin receptor antagonists can repair DNA after UV Damage. Apparently with extremely high does of X-ray the DNA repair state spins out of control.  Polyomaviruses binding serotonin receptors apparently triggers DNA regeneration as it infects and if a carcinogen is present with the virus cancer results.

Osteosarcomas have abnormally increased DNA levels
https://www.ncbi.nlm.nih.gov/pubmed/6958350

Serotonin receptors induce DNA repair after UV DNA damage
https://www.ncbi.nlm.nih.gov/pubmed/19829299

Serotonin protects against X-ray damage
https://www.karger.com/Article/Pdf/254512

polyomavirus sv40 and osteosarcoma
https://www.ncbi.nlm.nih.gov/pubmed/9824156?dopt=Abstract
http://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1000733

polyomavirus sv40 and papillary thyroid carcinomas
https://www.ncbi.nlm.nih.gov/pubmed/9482113?dopt=Abstract

x-rays and papillary thyroid carcinomas
http://www.thyroid.org/professionals/ata-publications/clinical-thyroidology/september-2013-volume-25-issue-9/clin-thyroidol-201325201-202/

x-rays and osteosarcoma
https://www.ncbi.nlm.nih.gov/pubmed/21170638

Polyomaviruses look like they are using serotonin receptors

JC and serotonin receptors
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3838264/
https://www.ncbi.nlm.nih.gov/pubmed/15550673

Serotonin receptors localized at the smooth endoplasmic reticulum
http://www.sciencedirect.com/science/article/pii/S000689930002062X

Bk and ganglioside receptors which pass through the Endoplasmic reticulum
https://experts.umich.edu/en/publications/identification-of-gangliosides-gd1b-and-gt1b-as-receptors-for-bk-

Gangliosides and sv40 virus
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC202381/

serotonin was once considered an ganglioside?

Both serotonin and gangliosides are stored in the smooth ER

antibodies overlap for serotonin and gangliosides
http://www.sciencedirect.com/science/article/pii/0306453092900172

Iron binding proteins have been shown to be regulated by serotonin receptors too
http://www.mc.vanderbilt.edu/reporter/index.html?ID=6991

Osteosarcomas and increased iron?

osteosarcomas, dogs, iron, and artemisinin
http://www.dogsnaturallymagazine.com/artemisinin-and-canine-cancer/

Artemisinin binds iron!!

artemisinin a sweet wormwood component