Bladder cancers and the linked viruses
Urothelial or transitional and EBV
http://onlinelibrary.wiley.com/doi/10.1111/j.1464-410X.2003.04687.x/full
hypermethylation and urothelial
https://www.ncbi.nlm.nih.gov/pubmed/16775427
Superficial or early non muscle bladder cancer and HPV
https://www.researchgate.net/publication/273783288_Low_prevalence_of_HPV_detection_and_genotyping_in_non-muscle_invasive_bladder_cancer_using_single-step_PCR_followed_by_reverse_line_blot
CIS carcinoma in situ and HIV ? (the flat bladder cancers)
Other thoughts
E-cadherin expression in Bladder cancers
https://www.ncbi.nlm.nih.gov/pubmed/15129905
"Normal urothelium, high-grade urothelial dysplasia/carcinoma in situ, and superficial noninvasive papillary urothelial carcinoma maintained E-CD expression."
The hypermethylated Translational group did not express E-caderin.
E-cadherin is responsible for cells holding in place and when the gene for it is methylated this anchor is no longer made and cells have the ability to metastasize
https://www.ncbi.nlm.nih.gov/pubmed/21059597
This means that the slow growing cancers that are started by herpes viruses that methylate are more likely to have the ability to leave the area, metastasize.
However reading this they seem to think that the superficial is an early form of cancer not a separate type...hmm.
Urothelial or transitional and EBV
http://onlinelibrary.wiley.com/doi/10.1111/j.1464-410X.2003.04687.x/full
hypermethylation and urothelial
https://www.ncbi.nlm.nih.gov/pubmed/16775427
Superficial or early non muscle bladder cancer and HPV
https://www.researchgate.net/publication/273783288_Low_prevalence_of_HPV_detection_and_genotyping_in_non-muscle_invasive_bladder_cancer_using_single-step_PCR_followed_by_reverse_line_blot
CIS carcinoma in situ and HIV ? (the flat bladder cancers)
Other thoughts
E-cadherin expression in Bladder cancers
https://www.ncbi.nlm.nih.gov/pubmed/15129905
"Normal urothelium, high-grade urothelial dysplasia/carcinoma in situ, and superficial noninvasive papillary urothelial carcinoma maintained E-CD expression."
The hypermethylated Translational group did not express E-caderin.
E-cadherin is responsible for cells holding in place and when the gene for it is methylated this anchor is no longer made and cells have the ability to metastasize
https://www.ncbi.nlm.nih.gov/pubmed/21059597
This means that the slow growing cancers that are started by herpes viruses that methylate are more likely to have the ability to leave the area, metastasize.
However reading this they seem to think that the superficial is an early form of cancer not a separate type...hmm.
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