Thursday, April 13, 2017

Dividing up the estrogen positive breast cancers

Breast cancer shapes
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0143811

Triple negative has a more round shape (HPV viruses)
and has a strong association with cervical cancer
http://arizona.openrepository.com/arizona/handle/10150/623542

epithelial breast cells and CMV
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3063230/

EBV and transition in breast to mesenchymal
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4972522/

Previous post connected the alpha estrogen receptors to the herpes-gamma viruses and estrogen-related receptors with herpes-beta viruses.

CMV is a beta virus. Progesterone is an ERR.

CMV binds ERR
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4284536/

EBV is a gamma virus.

is this possible?

methylation and Estrogen positive breast cancers
http://angelabiggs.blogspot.com/2017/03/breast-cancer-methylation-demethylation.html

syncytin-1 (herv W)
syncytin-2 (herv F)

noticed pattern

Zygote - demethylation- Blastocyte- methylation- Epiblast (pluripotent cells)
       awakens Herv K                                Herv H/ Herv F

Epiblast  -demethylation  - PGCs  -  methylation -Fetus
                    Herv E                              Herv W

viruses:  HPV/flavivirus    Herpes/ polyomaviruses/ retroviruses
                   demethylation                     methylation


syncytin and breast cancer
https://www.ncbi.nlm.nih.gov/pubmed/17306327

HERVs are considered embyrogenic genes that are turned on during methylation.  Syncytin is the new name given to them when looking their involvement with cell adhesion of breast cancer cells to endothelial cells

Syncytin and Cell adhesion
https://www.ncbi.nlm.nih.gov/pubmed/16871371

transition and Herv K ? are some herv ks with methylation????
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5292751/

some Herv Ks seem linked to herpes viruses...during methylation even

Herv-w/ syncytin-1  and EBV in multiple sclerosis
https://virologyj.biomedcentral.com/articles/10.1186/s12985-017-0719-3

EBV and Her2 ?
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3031896/


Glucocorticoid and HHV8
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3708632/

high stress...high levels of cortisone does cause methylation
http://www.sciencedirect.com/science/article/pii/S2352289514000095

so HHV8 might not cause cancer until high stress or another virus methylates the DNA?





No comments:

Post a Comment