Monday, May 16, 2016

Amyotrophic lateral sclerosis and autoimmune cross-targeting: HPV and trichophyton concetricum? Or Aflatoxin caused?

Is ALS, amyotrophic lateral sclerosis, caused by autoimmune cross-targeting ? HPV and  Trichophyton concetricum ? 

My gut is telling me that these HPV vaccine triggered are cases are actually guillain barre and that the ALS is from the aflatoxin-like compound alone but because these cases were diagnosed as ALS it has to be kept open.

In the future it would be nice to varify that tau is there.

Tau protein as a marker for ALS

https://ftd.med.upenn.edu/uploads/media_items/phosphorylated-tau-candidate-biomarker-for-amyotrophic-lateral-sclerosis.original.pdf


HPV and ALS
http://health.usnews.com/health-news/blogs/on-women/2009/03/20/cdc-takes-closer-look-at-gardasil-and-paralysis

Gardasil contains the HPV of 16 and 18

since ALS has been linked to lung and testicular cancers we may be looking at a specific HPV

hpv 16 and 18 are involved with lung cancer
http://www.ncbi.nlm.nih.gov/pubmed/23317184

HPV 16 was found with testicular cancer
http://www.ncbi.nlm.nih.gov/pubmed/16119985

HPV could be using cannabinoid receptors. There are 2 types of cannabinoid receptors.  Type one is expressed by the central nervous system, lungs, liver and kidney.  Type 2 is expressed by the immune system.

The nerves that express the cannabinoid receptors
http://www.ncbi.nlm.nih.gov/pubmed/15927811

Both CB1and CB2 are expressed by skin nerve fibers.
http://www.ncbi.nlm.nih.gov/pubmed/15927811

CB1 receptor is expressed on testicular cells
http://www.ncbi.nlm.nih.gov/pubmed/16025865

So are we looking at HPV 16 and the CB1 receptors for ALS? if ALS is autoimmune then why no distinctive antibodies? the ones reported sound like guillain barre.

Trichophyton cencetricum and ALS...definitely connected but is autoimmune cross-targeting with herpes or is it from the aflatoxin like compound that is made that destroys the nerve?

Aflatoxin like compounds are made by some dermatophytes
http://www.ncbi.nlm.nih.gov/pubmed/1170494
specifically T.concetricum

Guam has high rates of ALS
https://gerontologist.oxfordjournals.org/content/early/2014/07/25/geront.gnu072.full.pdf

High rates of trichophyton concentricum on Solomon children (close to guam and makes you wonder if both areas share this infection)
https://www.researchgate.net/publication/281516255_Trichophyton_concentricum_in_skin_lesions_in_children_from_the_Salomon_Islands

ALS and lakes in new england
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3922844/

Has this t.concentricum moved into these lakes?

Earlier posts looking at ALS , tyrosol, and the tau protein:
http://angelabiggs.blogspot.com/2016/03/microtubule-disease-issues-aflotoxin.html
http://angelabiggs.blogspot.com/2016/02/tyrosol-as-quorum-of-trichophyton.html

How does one distinguish ALS from guillain barre if they are both attacks on the nerves? is it the larger infection ?

Tad-43 and ALS
http://www.ncbi.nlm.nih.gov/pubmed/18989684

the relationship between tad-43 and Tau proteins is being analyzed
http://www.alzheimersanddementia.com/article/S1552-5260(13)01524-0/abstract
http://neurolink.athenadiagnostics.com/tdp-43-the-third-protein-linked-to-alzheimers-disease/

Previously I had looked at the relationship of aflatoxin and Tau since aflatoxin binds to microtubules and tau is a microtubule associated protein.  Does aflatoxin damage/change the DNA and cause the Tad-43?

Garlic and frontal lobe dementia
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3074326/

Garlic compounds prevented the binding of aflatoxin to the DNA
http://www.tandfonline.com/doi/abs/10.1080/01635589109514116?journalCode=hnuc20

note that aspergillus grows on bulbs like onions and garlic....and i had previously believed this group had sensitivies/allergies to them (bulb plants) Do people with ALS have allergies?

Older post
http://angelabiggs.blogspot.com/2016/03/microtubule-disease-issues-aflotoxin.html

Furthermore: tyrosol from trichophyton could explain some of the vitiligo found in some ALS cases

Does Trichophyton make tyrosol as it's quorum??? I have no proof yet but this might explain vitiligo without addison's disease

Tyrosol inhibits tyrosinase (a step in melanogenesis)
http://www.ncbi.nlm.nih.gov/pubmed/24287915









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