Sunday, May 1, 2016

Can we use amantidine against Zika?

parkinson's drug works against west nile which is a flavivirus like Zika
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4779909/

same drug works against the flu virus
http://www.ncbi.nlm.nih.gov/pubmed/20179772

Amantadine works on the flu viral matrix protein
http://www.ncbi.nlm.nih.gov/pubmed/759556

what is a viral matrix protein: links the outer viral coat to the RNA inside
https://en.wikipedia.org/wiki/Viral_matrix_protein

Just published May 3...a derivative of amatadine called mematine protects cells in petri dishes from zika!!!

http://www.usatoday.com/story/news/2016/05/02/researchers-look-repurpose-approved-drugs-treat-zika-virus/83815714/

of course the drugs were originally believed to be simple antagonists of the NMDA receptor
http://www.ncbi.nlm.nih.gov/pubmed/7884411

the function of them must be on the viral matrix protein of the viruses involved


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