Dopamine receptors and the flu viruses: are flu viruses using them as door knobs to enter cells

There are 5 types of dopamine receptors
http://www.livestrong.com/article/141471-5-types-dopamine-receptors/

The flu virus has an affinity for dopamine cells
http://www.ncbi.nlm.nih.gov/pubmed/23251423

The blog post is going to make the hypothesis that flu viruses are using dopamine receptors as door knobs to enter cells and that the viruses have different affinities for them.  Imagine one door they open 90% of the time based on binding affinities and the rest 10%....but in reality is I don't know.

D2 receptors are connected to the movement disorders while the D4s are not based on antipsychotic drugs?   Haloperidol can trigger movement disorders through D2 while clozapine doesn't. Clozapine has a higher affinity for D4 receptors and stimulates those cells.

D4 receptors are found in the heart. D2 receptors on the other hand are found on the pancreas.

antibodies to D2 where found in Acute onset Pandas with "small choreiform movements" but not in the pandas-like chronic tics
http://www.ncbi.nlm.nih.gov/pubmed/26454143


Type A  Bird Flu and D4 (flu uses this receptor and destroys these cells) 

Flu virus attacking heart : bird flu H5N1and D4
http://www.mayoclinic.org/diseases-conditions/bird-flu/basics/complications/con-20030228
http://www.ncbi.nlm.nih.gov/pubmed/26552130
http://www.dailymail.co.uk/health/article-2795370/schoolgirl-12-dies-flu-virus-attacked-heart.html

Note that the bird flu leaves people at increased risk for parkinson's disease
https://nwpf.org/stay-informed/news/2009/08/bird-flu-virus-strain-leaves-survivors-at-increased-parkinson%E2%80%99s-disease-risk/

humans and birds use of dopamine to create vocalizations
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3362661/

note that the spanish flu of 1918 which was linked to parkinson's is genetically similar to the current day bird flu
http://news.nationalgeographic.com/news/2005/10/1005_051005_bird_flu.html



Most PANDAS have been connect to H1N1...by parents? Looking for references connecting D4.

Swine Flu and D2 : swine flu H3N2

Flu virus and pancreatic cells:  H3N2 or H1N1 and D2 on the pancreas
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3536404/
https://www.newscientist.com/article/dn22456-diabetes-linked-to-flu/
http://jvi.asm.org/content/87/1/597.full

Note that it was the swine flu H3N2 vaccine that triggered the narcolepsy
http://www.cdc.gov/vaccinesafety/concerns/history/narcolepsy-flu.html

interestingly the D2 receptors are down regulated in sleep deprivation
http://www.ncbi.nlm.nih.gov/pubmed/22573693

Clozapine alters sleep cycles
http://www.ncbi.nlm.nih.gov/pubmed/15085087

 Do kids with PANDAS have narcolepsy? some do.

http://www.movementdisorders.org/MDS/Journals/Clinical-Practice-E-Journal-Overview/Movement-Disorders-Clinical-Practice-E-Journal-Volume-1-Issue-4/Remitting-Tics-and-Narcolepsy-Overlap-Associated-with-Streptococcal-Infection-A-Case-Report.htm

narcolepsy and the hypothalamus cells...is this a specific unusual type of strep?
http://rarediseases.org/rare-diseases/narcolepsy/

How similar to D2 is D3? laughter and addiction are linked to D3
could the binding affinities be for both or slightly stronger for D3?

they seem similar in response to the antidepressant Tianeptine
http://www.ncbi.nlm.nih.gov/pubmed/11981225

kids with acute onset pandas have excessive eye movement and laughing
http://www.ncbi.nlm.nih.gov/pubmed/27166296

this paper talks about schizophrenia but what is important is the link between eye movement and the D3 receptor
http://www.ncbi.nlm.nih.gov/pubmed/11673801


H7N9 flu and D5

D5 is on the kidney

H7N9 and kidney issues
http://www.ncbi.nlm.nih.gov/pubmed/23992125
http://www.ncbi.nlm.nih.gov/pubmed/25579740
https://100dialysis.wordpress.com/2013/05/24/h7n9-kills-and-attacks-kidneys/

this flu can also trigger type one diabetes
http://jvi.asm.org/content/87/1/597.full


Neuroleptic malignant syndrome

The connection of the flu viruses, neuroleptic malignant syndrome, and dopamine receptors further validates that flu viruses are using dopamine receptors.

neuroleptic malignant syndrome has been found to develop when patients are given the anti-viral amantadine to combat brain flu virus encephalitis
http://www.ncbi.nlm.nih.gov/pubmed/11421428

This syndrome does not develop when the same anti-viral is given to combat west nile or other flaviviruses.  (which use melanocortin receptors)

Neuroleptic malignant syndrome appears to be connected to dopamine receptors
https://en.wikipedia.org/wiki/Neuroleptic_malignant_syndrome

note that the Haloperidol drug about that is known to use dopamine receptors also triggers neuroleptic malignant syndrome with combined with the anti-viral amantadine
http://www.ncbi.nlm.nih.gov/pubmed/2720007