Sunday, December 4, 2016

Puzzling out the herpes viruses and the estrogen receptors

CMV has an extra coating on capsid in cytosol
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC356711/pdf/jvirol00262-0261.pdf

CMV and Herpes simplex both cross the plasma membrane by fusion and move across cytoplasm to the nuclear pore
https://www.ncbi.nlm.nih.gov/pubmed/4370986

Is it in the cytosol that they bind to estrogen receptors?

Estrogen receptor locations
https://www.ncbi.nlm.nih.gov/pubmed/3695480

herpes and estrogen receptors
https://www.ncbi.nlm.nih.gov/pubmed/19846508

Heavy metals and estrogen receptors
https://www.ncbi.nlm.nih.gov/pubmed/10770491
https://www.ncbi.nlm.nih.gov/pubmed/12746304

The beta estrogen receptors move into the mitochondria while the alpha and the estrogen like move into the nucleus.

previous blog post
http://angelabiggs.blogspot.com/2016/08/attempting-to-match-up-herpes-viruses.html

Alpha-herpes viruses: Herpes simplex 1, herpes simplex 2,  herpes zoster : Estrogen-beta receptors (nerves and uterine tissue)

Beta-herpes viruses: CMV, HHV6, HHV7 :  Estrogen-related receptors (CMV binding confirmed)

Gamma-herpes viruses: EBV, HHV8 : Estrogen-alpha receptors (lymphocytes, breast involved)

CMV compared to herpes
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC356711/pdf/jvirol00262-0261.pdf
Herpes disrupts the plasma membrane while CMV does not. CMV had dense cytoplasmic bodies where as herpes viruses did not. (CMV binds the estrogen like receptor)

Herpes viruses and glycoproteins???
https://www.ncbi.nlm.nih.gov/pubmed/9770079

so do the capsid become imbedded in the plasma membrane first ? then release into the the cytoplasm without the coat? Where it then binds with the estrogen receptors?


HLA-DP2 and viruses like CMV ?
https://www.ncbi.nlm.nih.gov/pubmed/22797815

are these viruses with aromatic amino acid coats?


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