Wednesday, December 7, 2016

Is Language impairment and dyslexia connected to HLA-A3 and CMV / EBV ?

HLA and specific language impairment
https://jneurodevdisorders.biomedcentral.com/articles/10.1186/1866-1955-6-1

HLA-A1 short term memory issues
HLA-A3 expressive language ability problems
HLA-B8 and HLA-DQ receptive language issues

handedness and dyslexia
https://www.ncbi.nlm.nih.gov/pubmed/1574158
https://www.ncbi.nlm.nih.gov/pubmed/8533054

Many babies exposed to CMV have been shown to develop dyslexia
http://www.congenitalcmv.org/preschool.pdf

auditory neuropathy in infant after cmv infection
http://www.ncbi.nlm.nih.gov/pubmed/22789691

images of viruses infecting the brain
http://www.neurology.org/content/70/1/84.full.pdf


HLA-A3 and Progressive relapsing multiple sclerosis

progressive relapsing multiple sclerosis  expressive language issues
https://www.ncbi.nlm.nih.gov/pubmed/23374023

relapsing remitting multiple sclerosis and acute aphasia
https://www.ncbi.nlm.nih.gov/pubmed/15037704


Progressive relapsing:

Herpes-gamma (epstein barr) herpes-beta ( HHV6 )  HLA-A3

HLA-A3 and MS
https://www.ncbi.nlm.nih.gov/pubmed/993587
https://www.ncbi.nlm.nih.gov/pubmed/901638
https://www.ncbi.nlm.nih.gov/pubmed/2273414

ms and epstein barr
http://nn.neurology.org/content/3/5/e275.full.pdf
https://www.ncbi.nlm.nih.gov/pubmed/27725113
http://www.news-medical.net/news/20120106/Study-shows-how-Epstein-Barr-virus-triggers-MS.aspx

MS and HHV6 (herpes-beta)
https://www.ncbi.nlm.nih.gov/pubmed/20926836
https://www.ncbi.nlm.nih.gov/pubmed/21524958

seasonal MS relapses in italy
http://bmcneurol.biomedcentral.com/articles/10.1186/1471-2377-10-105

seasonal epstein barr
https://www.ncbi.nlm.nih.gov/pubmed/14520445

Relapsing remitting

Relapsing-remitting: Herpes-alpha (zoster family)/HSV1   HLA-B
https://www.ncbi.nlm.nih.gov/pubmed/1831772
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2931768/

Herpes zoster is a herpes-alpha virus which uses the beta-estrogen receptor. Beta-estrogen receptors cycle to the mitochondria which means that bursts of estrogen could reawaken the virus (mostly women)

this form of MS involves mitochondrial dysfunction
https://www.ncbi.nlm.nih.gov/pubmed/12559505
https://www.ncbi.nlm.nih.gov/pubmed/16392116/
https://www.ncbi.nlm.nih.gov/pubmed/19293237

(probably overlaps with alzheimer's)

HSV1 has been linked to spatial learning issues
http://ns.umich.edu/new/releases/21854-herpes-viruses-associated-with-cognitive-impairment




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