Wednesday, December 7, 2016

Zika could be using ACTH receptors: causing microcephaly and glaucoma!!

congenital glaucoma and steroid ACTH
https://www.ncbi.nlm.nih.gov/pubmed/16874997

zika causing glaucoma
https://www.sciencedaily.com/releases/2016/11/161130132813.htm

Microcephaly and Zika

Flaviviruses could be using melanocortin receptors.  Zika must have chosen the MCR2 receptor as it's main receptor.  MCR2 is also the ACTH receptor. ACTH is the first hormone used by the babies brain to grow.

melatonin protecting against flavivirus infection through competition with the receptors?
http://www.ncbi.nlm.nih.gov/pubmed/14962057

Zika and melanocortin receptors
http://angelabiggs.blogspot.com/2016/01/does-zika-virus-use-melanocortin.html

ACTH receptors are on the placenta which is how this virus crosses better than the others and ACTH is the critical baby's brain growth hormone.

Calcium and ACTH
http://www.ncbi.nlm.nih.gov/pubmed/6284662
http://www.ncbi.nlm.nih.gov/pubmed/4323934

Pituitary cushing disease which has the characteristic of high ACTH from a tumor  has calcium deposits...which makes you wonder what the displaced ACTH is doing if the virus uses the ACTH receptor.  This could explain the calcium deposits in the brains of babies with Zika.

Autoimmune cross-targeting hypothesis

The layering of 2 different infections on one target triggering autoimmune disease.  A viral infection marking the inside of the target then a bacterial, or fungal, or mycobacteria infection marking the outside.

Zika + campylobacteria/sutterella at the peripheral nerves = guillian barre
Zika + staph at the CNS = acute flaccid paralysis
Zika + strep at the brain = encephalitis
Zika + mycobacteria at the substantia nigra = parkinson's
Zika + spirochetes like H.pylori at the bone marrow = Idopathic thrombocytopenic purpura 

There are blog posts for these containing reference links.

Co-carcinogenesis 

Rous' hypothesis requires a virus and a carcinogen together to start cancer.  My co-carcinogenesis takes his further:  Carcinogens inhibit polymerases. (yes we have been told carcinogens cause DNA damage but I think their ability to inhibit polymerases causes most cancer. The cancers have patterns and are not that chaotic)

Alone a carcinogen would inhibit growth until a virus appears opens up the DNA and modifies the cell by binding telomeres, to create virus supplies forever.  The problem is the carcinogen inhibits the viral polymerase better than the human polymerase.  So instead of the virus making what it wants the infected cell is transformed into a cancer cell.

Zika + benzene at the  bone marrow = leukemia

Zika  + PCB at the prostate = prostate cancer???


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