The reason the new drug ocrelizumab works is because this form of multiple sclerosis was triggered by a polyomavirus cross-targeting with a larger infection (mycobacteria or staph).
Polyomavirus and CD20
https://www.ncbi.nlm.nih.gov/pubmed/11349723
Ocrelizumab is an anti-CD20
https://en.wikipedia.org/wiki/Ocrelizumab
Primary progressive MS : polyomavirus (hepatitis B, JC, BK) HLA-C
https://healthimpactnews.com/2014/new-study-hepatitis-b-vaccination-in-france-sparked-a-wave-of-new-cases-of-ms/
previous blog post about multiple sclerosis
http://angelabiggs.blogspot.com/2016/11/the-4-types-of-ms-viruses-and-hlas.html
Autoimmune cross-targeting hypothesis:
The layering of 2 different infections on one target cell type triggers autoimmune disease. A viral infection marking the inside of the target then a bacterial, or fungal, or mycobacteria, or spirochete infection marking the outside.
Note that a vaccine can trigger autoimmune disease by attracting the immune system to the receptor the virus would bind unless that piece is removed from the vaccine.
France and hepatitis B vaccine triggering MS
https://healthimpactnews.com/2014/new-study-hepatitis-b-vaccination-in-france-sparked-a-wave-of-new-cases-of-ms/
virus receptor binding
http://angelabiggs.blogspot.com/2016/12/viruses-and-benzene-rings.html
The infections are not causing the autoimmune disease it is the immune system which is uncoupled with a cross-targeting issue. Both the T cells and the B cells self educations cannot be turned off at the same time.
Polyomavirus and CD20
https://www.ncbi.nlm.nih.gov/pubmed/11349723
Ocrelizumab is an anti-CD20
https://en.wikipedia.org/wiki/Ocrelizumab
Primary progressive MS : polyomavirus (hepatitis B, JC, BK) HLA-C
https://healthimpactnews.com/2014/new-study-hepatitis-b-vaccination-in-france-sparked-a-wave-of-new-cases-of-ms/
previous blog post about multiple sclerosis
http://angelabiggs.blogspot.com/2016/11/the-4-types-of-ms-viruses-and-hlas.html
Autoimmune cross-targeting hypothesis:
The layering of 2 different infections on one target cell type triggers autoimmune disease. A viral infection marking the inside of the target then a bacterial, or fungal, or mycobacteria, or spirochete infection marking the outside.
Note that a vaccine can trigger autoimmune disease by attracting the immune system to the receptor the virus would bind unless that piece is removed from the vaccine.
France and hepatitis B vaccine triggering MS
https://healthimpactnews.com/2014/new-study-hepatitis-b-vaccination-in-france-sparked-a-wave-of-new-cases-of-ms/
virus receptor binding
http://angelabiggs.blogspot.com/2016/12/viruses-and-benzene-rings.html
The infections are not causing the autoimmune disease it is the immune system which is uncoupled with a cross-targeting issue. Both the T cells and the B cells self educations cannot be turned off at the same time.
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