The 4 types of MS, the viruses, and the HLAs

The 4 major types of MS and the HLAs

HLA-A the nucleus

HLA-B the mitochondria

HLA-C the endoplasmic reticulum

HLA-DR the cytosol (encapsulated virus)

HLA-DQ the cytosol (not an encapsulated virus)

HLA-DP the plasma membrane of immune system cells

Primary progressive 

Primary progressive : polyomavirus  (hepatitis B, JC, BK) HLA-C
https://healthimpactnews.com/2014/new-study-hepatitis-b-vaccination-in-france-sparked-a-wave-of-new-cases-of-ms/

children and HLA-C and multiple sclerosis
http://www.tandfonline.com/doi/abs/10.3109/08916930903567492?journalCode=iaut20

primary after RIS
http://multiple-sclerosis-research.blogspot.com/2015/12/primary-progressive-ms-after-ris.html

RIS and gray matter
http://www.medpagetoday.com/resource-center/multiple-sclerosis/radiologically-isolated-syndrome/a/44699

Gray matter and childhood MS
https://www.ncbi.nlm.nih.gov/pubmed/26445729
https://www.facebook.com/notes/ccsvi-in-multiple-sclerosis/loss-of-gray-matter-in-pediatric-ms/10150216042297211/

gray matter and endoplasmic reticulum stress
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4518158/
http://www.ms-society.ie/uploads/File/Research/MS%20Ireland%20Final%20Report_FitzGerald_McMahon_McQuid_July2010.pdf

gray matter and hepatitis B ?
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0119339

to set off autoimmunity it just has to trigger the immune system as foreign it doesn't need to be active

If the JC becomes active PML can occur ? (MS medication Natalizumab )
http://www.medicalnewstoday.com/articles/311022.php

JC virus involves white matter and the demyelination of the brain (alien hand syndrome common where they lose control of a hand)

these polyomaviruses can hide dormant in the endoplasmic reticulum much like herpes zoster can hide dormant in the mitochondria

previously I examined vit D, polyomaviruses, and alopecia
http://angelabiggs.blogspot.com/2016/10/vitamin-d-receptor-and-polyomaviruses.html

the VDR (vit D receptor) gene increased the risk specifically for progressive multiple sclerosis
https://www.ncbi.nlm.nih.gov/pubmed/16076630

these polyomaviruses appear to use Serotonin receptors to enter cells and end up in the ER next to Vit D

Relapsing remitting

Relapsing-remitting: Herpes-alpha (zoster family)  HLA-B
https://www.ncbi.nlm.nih.gov/pubmed/1831772
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2931768/

Herpes zoster is a herpes-alpha virus which uses the beta-estrogen receptor. Beta-estrogen receptors cycle to the mitochondria which means that bursts of estrogen could reawaken the virus (mostly women)

this form of MS involves mitochondrial dysfunction
https://www.ncbi.nlm.nih.gov/pubmed/12559505
https://www.ncbi.nlm.nih.gov/pubmed/16392116/
https://www.ncbi.nlm.nih.gov/pubmed/19293237


Secondary progressive

secondary progressive : Flavivirus (Hepatitis C/dengue/ west nile) HLA-DR15  (20%)

https://www.ncbi.nlm.nih.gov/pubmed/21475933
https://www.ncbi.nlm.nih.gov/pubmed/17329717
https://www.ncbi.nlm.nih.gov/pubmed/10939572

secondary progressive MS is more common in mexico than primary because flaviviruses are more common there 

 http://ijmsc.org/doi/abs/10.7224/1537-2073-7.4.143

 cases of dengue fever in multiple sclerosis
https://www.ncbi.nlm.nih.gov/pubmed/27063625
http://jamanetwork.com/journals/jamaneurology/article-abstract/2548265

guillian barre overlapping MS
https://www.hindawi.com/journals/ad/2012/232139/
http://link.springer.com/article/10.1007%2FBF00314120

devic's and ms?

Progressive relapsing: (are some of these diagnosed as secondary?)

Herpes-gamma (epstein barr) herpes-beta ( HHV6 )  HLA-A

HLA-A3 and MS
https://www.ncbi.nlm.nih.gov/pubmed/993587
https://www.ncbi.nlm.nih.gov/pubmed/901638
https://www.ncbi.nlm.nih.gov/pubmed/2273414

ms and epstein barr
http://nn.neurology.org/content/3/5/e275.full.pdf
https://www.ncbi.nlm.nih.gov/pubmed/27725113
http://www.news-medical.net/news/20120106/Study-shows-how-Epstein-Barr-virus-triggers-MS.aspx

MS and HHV6 (herpes-beta)
https://www.ncbi.nlm.nih.gov/pubmed/20926836
https://www.ncbi.nlm.nih.gov/pubmed/21524958

seasonal MS relapses in italy
http://bmcneurol.biomedcentral.com/articles/10.1186/1471-2377-10-105

seasonal epstein barr
https://www.ncbi.nlm.nih.gov/pubmed/14520445

epstein barr in lymphocytes of multiple sclerosis
https://www.ncbi.nlm.nih.gov/pubmed/6309449?dopt=Abstract&holding=npg

other genes and progressive relapsing: TCR  (T cell receptor protein)
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1376877/

TCR protein and estrogen alpha-receptors
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC315468/

I am not sure how this fits together but herpes-gamma look like they use the estrogen alpha-receptors.

Extra notes

Autoimmune cross-targeting hypothesis: when 2 infections simultaneously infect a target, a virus inside and a larger infection outside that triggers autoimmune disease.  Mycobacterias or staph infecting the outside of the nerves while one of these viruses infects the inside.

late onset mycobacteria/psoriasis HLA-dr6
early onset staph/eczema HLA-dr15

Note that HLA-DR1.04  seems connected to a secreted bacterial/mycobacterial protein and this hasn't been figured out yet while HLA-DP might indicate something fungal? Green tea kills mycobacteria and lots of bacteria which would explain the expression HLA change for japan. Perhaps other infections like aspergillus could be involved in japan?

HLA-dp and Japan
http://europepmc.org/abstract/med/9756407