Hypotheses: Autoimmune Cross-targeting, Co-carcinogenesis, and Quorum complications : HLA-B16, B38, B39 and mycobateria? Are these HLAs B16 the apoptosis mitochondria linked to cytochrome C release?

Thursday, November 10, 2016

HLA-A the nucleus

HLA-B the mitochondria

HLA-C the endoplasmic reticulum

HLA-DR the cytosol (encapsulated virus or foreign protein)

HLA-DQ the cytosol (not an encapsulated virus)

cytochrome C release could cause the blistering

Cantharidin a compound from Blister Beetles has been shown to decrease mitochondrial cytochrome C and increase cytosolic cytochrome C

mycobacteria and HLA-B38? not just clozapine? DQB1.0201 ?

Schziophrenia with Agranulocytosis 80% have HLA-B38...from clozapine?
Agranulocytosis is extremely low white blood cell count (neutrophils?)
https://www.ncbi.nlm.nih.gov/pubmed/11281944

HLA-B16 is split into B38 and B39...compared binding motifs
http://link.springer.com/article/10.1007/s00251-015-0898-2

HLA-B39 links to Takayasu's (mycobacteria) and Chagas (t.cruzi) in heart
https://en.wikipedia.org/wiki/HLA-B39

HLA-B16 I had connected to beta herpes like Zoster and simplex..in schizo but maybe this is wrong and it was the type of mycobacteria?????

Herpes Zoster and simplex are know to alter cell cycles
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC353735/

Are the B38 and B39 also involved with mitochondrial??

Looking at the genetic cause of agranulocytosis called Kostmann disease it looks like mitochondrial apoptosis is involved
http://www.omim.org/entry/610738

protein localizes to mitochondria
https://www.ncbi.nlm.nih.gov/pubmed/9058808

Hypotheses: Autoimmune Cross-targeting, Co-carcinogenesis, and Quorum complications