Sunday, November 6, 2016

Bell's Palsy as autoimmune cross-targeting: spirochetes and flu viruses

Autoimmune cross-targeting hypothesis

The layering of 2 different infections on one target triggering autoimmune disease.  A viral infection marking the inside of the target then a bacterial, or fungal, or mycobacteria infection marking the outside.

bell's palsy and spirochetes
http://www.ncbi.nlm.nih.gov/pubmed/2589070bBorrelia
http://www.ncbi.nlm.nih.gov/pubmed/1632233 Borrelia
http://www.ncbi.nlm.nih.gov/pubmed/365078 Syphilis
http://www.ncbi.nlm.nih.gov/pubmed/12284236 syphilis
http://www.ncbi.nlm.nih.gov/pubmed/25648561 Leptospira
http://www.ncbi.nlm.nih.gov/pubmed/21613003 Leptospira
http://www.ncbi.nlm.nih.gov/pubmed/15287387 Leptospira

bell's palsy and herpes simplex???
http://www.ncbi.nlm.nih.gov/pubmed/9393551
http://www.ncbi.nlm.nih.gov/pubmed/16917546

is bell's palsy an autoimmune disease?
http://www.ncbi.nlm.nih.gov/pubmed/22684016 
http://www.ncbi.nlm.nih.gov/pubmed/22934210
http://www.ncbi.nlm.nih.gov/pubmed/51046  (compares it to guillian barre)

HLAs and Bell's Palsy
http://jamanetwork.com/journals/jamaotolaryngology/article-abstract/613342

The immune system is telling us that it is not herpes simplex ( would have been HLA-B)

HLA-DR2
HLA-DR4
HLA-DRW6
HLA-DRW7

which looking at the HLAs indicates this is triggered by the flu viruses!! HLA-DR2 and HLA-D4
Bell's Palsy has been known to start 2 weeks after a flu like episode.

Bell's Palsy and flu vaccine
http://www.medscape.com/viewarticle/763332
https://www.zocdoc.com/answers/3257/how-are-bells-palsy-and-the-flu-shot-related

The key here is to develop a vaccine that does not trigger the autoimmune bells palsy. (note that it is the flu virus antigen that actually triggers the autoimmune disease) We need to remove the receptor binding element of the vaccines so it can't get into cells and trigger the autoimmunity.

The HLA-DRw6 and HLA-DRw7 could be from the spirochete infection. I am looking at other possible spirochete infections for matches.






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