HLA-DP, APCs and large infections' antigen (digested then presented)

HLA-DP are the HLAs of Antigen Presenting Cells and exist on the plasma membrane surface where they interact with large infections

HLA-DP and transplants
https://www.ncbi.nlm.nih.gov/pubmed/16340798

HLA-DP3 and stem cells
https://www.ncbi.nlm.nih.gov/pubmed/23619468

This page is likely to change...hypotheses are not proven.


HLA-DP1 and E.coli or spirochetes (glycoprotein coats?)

HLA-DPw1 and Celiac (e.coli)
https://www.ncbi.nlm.nih.gov/pubmed/1971269


HLA-DP A1 and h.pylori
https://www.ncbi.nlm.nih.gov/pubmed/10514120

e.coli and glycoproteins
https://www.researchgate.net/publication/10811116_Bacterial_glycoproteins_Functions_biosynthesis_and_applications

spirochetes and glycoprotein coat
http://www.lymeneteurope.org/info/the-complexities-of-lyme-disease

viruses and glycoprotein coats: hepatitis B and ebola

Hepatitis B and glycoprotein coats
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC20001/

HLA-DpA1 and Hepatitis B
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3308944/

Ebola and glycoproteins
http://jvi.asm.org/content/89/2/1205.full

HLA-DPA1 and Ebola
https://in-silico-pharmacology.springeropen.com/articles/10.1186/s40203-015-0011-4



HLA-DP2 and fungal infections with the heavy metals

Mycorrhiza fungus collects heavy metals protecting the roots of plants.  Could aspergillus and candida be doing the same thing? grabbing and holding on to heavy metals?

HLA-DP? and Candida
http://ard.bmj.com/content/50/10/697.full.pdf

HLA-DP and aspergillus
https://idsa.confex.com/idsa/2010/webprogram/Paper5035.html

HLA-DP and Sjogren's
https://www.ncbi.nlm.nih.gov/pubmed/8485911

HLA- DP and SLE
http://www.tandfonline.com/doi/abs/10.3109/08916939009002976

Benzene/armomatic amino acid rings and candida?

https://books.google.com/books?id=1CvTBlGBicwC&pg=PA422&lpg=PA422&dq=aromatic+rings+candida&source=bl&ots=WNXjEofCLZ&sig=1FZWMuh8auO8HVS_9zTnxm0tG5g&hl=en&sa=X&ved=0ahUKEwjEnfWg8svQAhVmj1QKHXfpAVYQ6AEIKzAD#v=onepage&q=aromatic%20rings%20candida&f=false

beryllium and benzene
https://www.ncbi.nlm.nih.gov/pubmed/24336592

HLA-DP2 and benzene/aromatic amino acid rings?
http://bmcstructbiol.biomedcentral.com/articles/10.1186/1472-6807-11-32

HLA-DP2 and beryllium disease
https://www.ncbi.nlm.nih.gov/pubmed/24995984

EBV and HLA-DP
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC111730/

HLA-DP2 and viruses like CMV
https://www.ncbi.nlm.nih.gov/pubmed/22797815

heavy metals can bind estrogen receptors so perhaps the HLA-DP2 can bind the antigen of the herpes viruses ( the part that attempts to bind the estrogen receptors)

Heavy metals and estrogen receptors
https://www.ncbi.nlm.nih.gov/pubmed/10770491
https://www.ncbi.nlm.nih.gov/pubmed/12746304

HLA-DP3 and mycoplasmas  (phospholipids?)

Mycoplasmas have simple phospholipid membranes.

mycoplasmas and glycerophospholipids GG and CL
https://www.hindawi.com/journals/jl/2012/640762/

The autoimmune diseases associated with mycoplasmas also have associations with HLA-DP

HLA-DPw3 and Rheumatoid arthritis
https://www.ncbi.nlm.nih.gov/pubmed/3259737

HLA-DP3 and type one diabetes or anti-phospholipid syndrome

Graves and HLA-dp
https://www.ncbi.nlm.nih.gov/pubmed/3120348

HLA-DP and cervical cancer (are these HLA-DP3?)
https://www.ncbi.nlm.nih.gov/pubmed/26711785
https://www.ncbi.nlm.nih.gov/pubmed/23428460

Note that HPV which causes cervical cancer has a phospholipid binding protein on it's capsid surface, Do they bind and drag phospholipids around with them?


HLA-DP4 and staph or Toxoplasma (Hemagglutinin which binds mucin)

HLA-DP4 is the most common HLA group II...60% of the world's population
https://www.ncbi.nlm.nih.gov/pubmed/12471126

HLA-DP4 's binding region is similar to HLA-DP2 which binds heavy metals (aromatic rings)

tyrosine corners of staph and flu's hemagglutin
http://www.sbb.duke.edu/downloads/622/files/1994_Hemmingsen_TyrCorner_ProSci.pdf

tyrosine and sialic bind ?

HLA-DP4 recognizes hemagglutinin
http://jvi.asm.org/content/70/7/4787.short

Hemagglutinin binds the sialic acid of mucin
https://www.ncbi.nlm.nih.gov/pubmed/24233973

staph binds to mucin
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC173761/

t.gondii and mucin binding
http://grantome.com/grant/NIH/R01-AI095094-01A1

The heart disease group of T. cruzi is connected to DPB1.04
https://www.ncbi.nlm.nih.gov/pubmed/10689123

HLA-DP and staph
https://www.ncbi.nlm.nih.gov/pubmed/2658055
https://www.ncbi.nlm.nih.gov/pubmed/?term=hla-dp+staph

http://research.ku.dk/search/?pure=en/publications/inhibition-of-allostimulated-hladq-and-dpspecific-t-cells-by-staphylococcal-enterotoxin-a(ef2d70f0-fd95-11dd-b219-000ea68e967b).html

HLA-DPw4 and multiple sclerosis (staph can trigger autoimmune disease)
https://www.ncbi.nlm.nih.gov/pubmed/2641759

HLA- DPw4 and Alopecia (staph can trigger autoimmune disease)
https://www.ncbi.nlm.nih.gov/pubmed/2375044

RSV virus and HLA-DP4
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC369497/

Viral fusion proteins and tyrosine tails
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3035738/

 paramyxovirus viruses and HLA-DP4?

HLA-DP5 and strep (M protein)

HLA-DP5 and strep
https://www.ncbi.nlm.nih.gov/m/pubmed/8863870/

M protein are protein sequences which look like immunoglobulins (antibodies)

HLA-DP5 and immunoglobulin binding in regard to pollen allergy
https://www.ncbi.nlm.nih.gov/pubmed/25020231

note that children with allergic rhinitis (hay fever caused by pollen allergies) doubled the the risk of developing tourettes...which has been linked to strep infecitons
http://www.tsplusblog.com/2011/03/allergies-are-associated-with-increased-rates-of-tourettes-syndrome-study/


Mycobacterias are growing inside cells so why can't I find an HLA-dp for when they leave?