Monday, November 7, 2016

Is HLA-DR6, HLA-DR13, and HLA-DR14 for citrullination inside of or on cells?

HLA-DR6, HLA-DR13, and HLA-DR14 and Citrullination inside of or at cell?

HLA-DR14 and MG
https://www.ncbi.nlm.nih.gov/pubmed/16769963
https://www.ncbi.nlm.nih.gov/pubmed/23993985

HLA-DR14 and HLA-DR4 in Rheumatoid arthritis
https://www.ncbi.nlm.nih.gov/pubmed/21125177

MG, still's, brown's, and mycoplasmas
http://angelabiggs.blogspot.com/2016/06/myasthenia-gravis-browns-syndrome.html

JIA
HLA-DR4 and HLA-DR6
https://www.ncbi.nlm.nih.gov/pubmed/24618287

measles and HLA-DR13 (non response to vaccine?)
https://www.ncbi.nlm.nih.gov/pubmed/8763977

measles and citrullination
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3799991/

hepatitis B and citrullination
https://www.ncbi.nlm.nih.gov/pubmed/19286846

RA and citrullination
http://www.news-medical.net/news/20131031/Scientists-unravel-the-major-cause-of-protein-citrullination-in-rheumatoid-arthritis.aspx

P. Gingivalis and citrullination (note that this was the HLA-DR1 group but we are looking at it now to compare with mycoplasmas)
http://www.roadback.org/forums/topic/pathogens-and-seropositive-ra/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4131749/

note that arginine deaminase inhibits gingivalis attachment
https://www.researchgate.net/publication/233931217_Arginine_Deiminase_Inhibits_P_gingivalis_Surface_Attachment

I don't think that only gingivalis is an issue in RA because some mycoplasmas use arginine and attach to cells using arginine too

some mycoplasmas attach to cells and use arginine
https://books.google.com/books?id=YmEoAv_eQ3EC&pg=PA154&lpg=PA154&dq=mycoplasma+attach+arginine&source=bl&ots=ws1fi5f34s&sig=mHWiUkK4eX4A65EMHGpq8VKq2Es&hl=en&sa=X&ved=0ahUKEwismdXG4JbQAhVE02MKHUEkDIwQ6AEISTAJ#v=onepage&q=mycoplasma%20attach%20arginine&f=false

(under citrullination : arginine becomes citrulline)

problem: takayasu and hla-dr6....that's a mycobacteria?

patients with pulmonary tuberculous has antibodies to cyclic citrullinated proteins
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3621955/

This would mean that late onset MS would be mycobacteria with HLA-DR6







No comments:

Post a Comment