Cross-targeting triggering Rheumatoid arthritis. Can the HLAs reveal the viruses

Autoimmune cross-targeting hypothesis

The layering of 2 different infections on one target triggering autoimmune disease.  A viral infection marking the inside of the target then a bacterial, or fungal, or mycobacteria infection marking the outside.

Rheumatoid arthritis would be mycoplasmas marking the outside of the tendon then a virus marking the inside.

mycoplasmas and rheumatoid arthritis
https://www.ncbi.nlm.nih.gov/pubmed/11128659
https://www.ncbi.nlm.nih.gov/pubmed/8943749
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1006269/?page=1
https://www.ncbi.nlm.nih.gov/pubmed/4948122

mycoplasmas and tendons
https://www.ncbi.nlm.nih.gov/pubmed/18766866
https://www.ncbi.nlm.nih.gov/pubmed/18766674

Sjogren's would not be mycoplasmas rather candida marking the outside then a virus on the inside.

Sjogren's and candida
https://www.ncbi.nlm.nih.gov/pubmed/21844143

HLA are the the T cell mailboxes that show what foreign things are inside the cell which often times is a virus.  Viruses infect different areas of the cell and tend to be grabbed by the same mailbox HLA.

HLA-A nucleus
HLA-B mitochondria
HLA-C endoplasmic reticulum
HLA-DR encapsulated virus in cytosol on antigen presenting cell
HLA-DQ non encapsulated virus in cytosol on antigen presenting cell
HLA-DP antigen presenting cells' HLA on surface plasma membraine

note that when the infected cell is popped...the APC still cannot see inside the nucleus, the mitochondria or ER membranes which is why the HLAs are there


HLA- DR 
Rheumatoid vasculitis HLA-DR4 flu
https://www.ncbi.nlm.nih.gov/pubmed/16762149

Rheumatoid vasculitis after flu vaccine
http://rheumatology.oxfordjournals.org/content/42/7/907.full

 rheumatoid and SJ with raynaud's has HLA-dr4
https://www.ncbi.nlm.nih.gov/pubmed/6605120

high RF

diabetes and rheumatoid (both can be triggered by the flu)
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2768389/

Flu viruses use dopamine receptors

Tendons and dopamine ?? parkinson's and tendon issues
http://ama.ba/index.php/ama/article/viewFile/159/pdf

Parkinson's caused by Rheumatoid drug
https://academic.oup.com/rheumatology/article/42/5/702/1784801/Severe-Parkinson-s-disease-in-rheumatoid-arthritis

Infliximab or remicade binds TNF alpha which is made not just by macrophages but my neurons

If the flu is still there marking the inside of the substantia nigra (infected through dopamine receptors) and then suddenly a foreign compound marks the outside of the cells because of the TNFalpha  it is possible that cross-targeting could occur causing the parkinson's following RA...but the key is the flu virus is still there and active when the remicade like drug is given.



HLA-A
Rheumatoid with lupus linked HLA-A2 EBV (HLA-A3 CMV)

high RF
ANA anti-nuclear antibody

HLA-All and lupus (HLA-All and CMV)
https://www.ncbi.nlm.nih.gov/pubmed/21658414

EBV and lupus
https://www.ncbi.nlm.nih.gov/pubmed/17121489

EBV use alpha estrogen receptors and CMV uses estrogen-like receptors.

Tendons and estrogen
https://www.ncbi.nlm.nih.gov/pubmed/18845777

Note that other viruses could possibly trigger RA but the HLAs should match up.  Here's a previous blog post where i was looking at retroviruses
http://angelabiggs.blogspot.com/2016/10/rheumatoid-arthritis-hla-drb1-and_24.html




CRP C-reactive protein : produced in the liver during inflammation

ANA anti-nuclear antibody

RF is an antibody directed against an antibody

ESR erythrocyte sedimentation rate