Autoimmune cross-targeting hypothesis: a virus marks the inside of a cell while a larger infection marks the outside and the combination triggers autoimmune disease. The immune system is instructed to destroy both the inside and the outside of the target.
Is ALS cross-targeting on the anterior horn cells? An enterovirus on the inside and trichophyton on the outside?
ALS and the poliovirus similarities
http://www.ncbi.nlm.nih.gov/pubmed/7611634
Enterovirus and ALS
http://www.ncbi.nlm.nih.gov/pubmed/19900148
http://www.webmd.com/brain/news/20000113/could-virus-cause-lou-gehrigs-disease
http://www.ncbi.nlm.nih.gov/pubmed/9021257
http://www.ncbi.nlm.nih.gov/pubmed/15208080
https://books.google.com/books?id=jjvFj6aQeMgC&pg=PA315&lpg=PA315&dq=virus+ALS&source=bl&ots=gTQCdz7kl7&sig=QtiMKeHVDsScRBdZK8fnkIXTirI&hl=en&sa=X&ved=0CDIQ6AEwAzgUahUKEwjnze-38tXHAhVLpIgKHb3MBpg#v=onepage&q=virus%20ALS&f=false
note that some researchers can't find the enterovirus in ALS patients?
http://www.ncbi.nlm.nih.gov/pubmed/15111658
What would the larger infection be Trichophyton?
Trichophyton has a wood rot variety. This could be found in rotting beaver dams....which might explain the ALS clusters around lakes in north America.
http://link.springer.com/article/10.3839%2Fjksabc.2010.026#page-1
Can infections of the feet explain the sport association of ALS? Lou Gehrig's disease
Trichophyton is the most common skin fungus and causes athletes foot.
http://www.ncbi.nlm.nih.gov/pubmed/18578874
Als and scalp issues: a forum's comments
http://www.alsforums.com/forum/archive/index.php?t-1141.html
trichophyton and the scalp
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1521225/
http://www.ncbi.nlm.nih.gov/pubmed/25322706
Pick's disease and ALS
http://www.ncbi.nlm.nih.gov/pubmed/3322801
http://www.ncbi.nlm.nih.gov/pubmed/21369423
http://www.ncbi.nlm.nih.gov/pubmed/8410013
http://www.ncbi.nlm.nih.gov/pubmed/15068178
Picks is in the frontal and temporal lobes and involves Tau
Hyperphosphorylated Tau has been found in ALS
http://www.ncbi.nlm.nih.gov/pubmed/16769962
http://www.ncbi.nlm.nih.gov/pubmed/17713769
Other thoughts:
ALS skin changes
http://www.ncbi.nlm.nih.gov/pubmed/3714056
http://www.ncbi.nlm.nih.gov/pubmed/2769298
ALS itchy skin
http://www.alsforums.com/forum/general-discussion-about-als-mnd/15654-itchy-skin.html
could this be a sign of nerve damage at the skin starting the disease?
Currently they are studying the ability of Keratin to stimulate nerve growth
http://www.news-medical.net/news/20101202/DOD-awards-24224-million-grant-to-study-keratin-gel-in-peripheral-nerve-regeneration.aspx
This fungus destroys toenails too. I feel like we are missing something here about the fungus and it marking the outside of these nerves perhaps because of keratin?
The skin's hairs are embedded in a layer of skin nerve cells which are unmyelinated....so is it an autoimmune attack starting at these nerves? which turns into motor neurons?
ALS and neuronal filaments
http://www.sciencedirect.com/science/article/pii/S0925443906001761
Bunina bodies, the tau we see, does it appear because of a neurofilament issue with this fungus?
Can coconut oil slow Trichophyton growth?
http://www.ncbi.nlm.nih.gov/pubmed/1302812
http://www.ncbi.nlm.nih.gov/pubmed/8264720
Please see newer posts 2016....ALS might not be autoimmune but could be related to an aflotoxin-like compound and Tau.
http://angelabiggs.blogspot.com/2016/03/microtubule-disease-issues-aflotoxin.html
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