Thursday, August 6, 2015

Does Autoimmune Cross-targeting trigger Addison's disease?

Autoimmune cross-targeting hypothesis: a virus marks the inside of a cell while a larger infection marks the outside and the combination triggers autoimmune disease.  The immune system is instructed to destroy both the inside and the outside of the target.


Autoimmunity and the adrenal glands
http://www.ncbi.nlm.nih.gov/pubmed/26240101
triggered by the flu virus?

addison's and the flu
http://www.ncbi.nlm.nih.gov/pubmed/4698728
http://www.ncbi.nlm.nih.gov/pubmed/13985224
http://www.ncbi.nlm.nih.gov/pubmed/26240101

That would mean the adrenal glands had D2 receptors

D2 receptor and the adrenal glands
http://www.ncbi.nlm.nih.gov/pubmed/11549694
http://www.ncbi.nlm.nih.gov/pubmed/2960326

What would be the larger infection on the outside of the adrenal glands?

Primary infection of adrenal glands tends to be fungal infections:
http://www.ncbi.nlm.nih.gov/pubmed/14513986
http://www.uptodate.com/contents/causes-of-primary-adrenal-insufficiency-addisons-disease

Polyglandular syndrome one vs 2

 APS 1 involves children and candida
APS 2 involves adults, no candida which means other fungal infections?, more women than men, addison's

Both have hypothyroid associated

APS 2 is also called Schmidt's syndrome
which can also be associated with scarcoidosis
http://www.ncbi.nlm.nih.gov/pubmed/8935608

Scarsoidosis is increasingly connected to fungal infections
http://www.ehjournal.net/content/10/1/8
http://annals.org/article.aspx?articleid=676878

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