Monday, August 3, 2015

Rheumatic Fever autoimmunity as cross-targeting

Autoimmune cross-targeting hypothesis: a virus marks the inside of a cell while a larger infection marks the outside and the combination triggers autoimmune disease.  The immune system is instructed to destroy both the inside and the outside of the target.


Strep and coxsackie causing rheumatic fever together...already proven in the heart?
http://www.ncbi.nlm.nih.gov/pubmed/18608177
http://www.ncbi.nlm.nih.gov/pubmed/25191648
http://www.ncbi.nlm.nih.gov/pubmed/8244506
http://www.ncbi.nlm.nih.gov/pubmed/227971
http://www.ncbi.nlm.nih.gov/pubmed/10021888
http://medind.nic.in/imvw/imvw17247.html
http://www.ncbi.nlm.nih.gov/pubmed/2561125

sydenhams chorea which is the rheumatic reaction in the brain (is this cross-targeting too?)
http://www.ncbi.nlm.nih.gov/pubmed/24184556

coxsackie and the basal ganglia
http://www.ncbi.nlm.nih.gov/pubmed/3425221

strep and the basal ganglia
http://www.ncbi.nlm.nih.gov/pubmed/22617826

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