Tuesday, August 25, 2015

Can polymyositis, inclusion body myositis, and dermatomyositis be explained by this autoimmune cross-targeting hypothesis?

Autoimmune cross-targeting hypothesis: a virus marks the inside of a cell while a larger infection marks the outside and the combination triggers autoimmune disease.  The immune system is instructed to destroy both the inside and the outside of the target.

Polymyositis and Inclusion body myositis: cross-targeting of skeletal muscles

Auto-antibodies like Sjogren's which hints of fungal infection

Is Polymyositis a candida like infection cross-targeting with coxsackie B while inclusion body myositis is chytrid cross-targeting with coxsackie?

Polymyositis been triggered by Coxsackie B
http://www.ncbi.nlm.nih.gov/pubmed/18432367
http://www.ncbi.nlm.nih.gov/pubmed/631901
http://www.ncbi.nlm.nih.gov/pubmed/5490731

Polymyositis and other fungal infections like Candida
http://www.ncbi.nlm.nih.gov/pubmed/15818648

Frogs can have inclusion body myositis: virus and chytrid fungus
http://www.ncbi.nlm.nih.gov/pubmed/12423034

The fungus chytrid that kills frogs hides in crayfish
http://phenomena.nationalgeographic.com/2012/12/18/fungus-bd-frog-crayfish-chytrid/

Regions that eat crayfish like Tennesse should have clusters of Inclusion body myositis: do they?

Electrolytes in frogs infected with chytrid were low
http://www.abc.net.au/science/articles/2009/10/23/2720384.htm?site=science/tricks&topic=latest

Polymyositis and low potassium
http://www.ncbi.nlm.nih.gov/pubmed/3430508

Clay eating and myositis
http://www.ncbi.nlm.nih.gov/pubmed/3340881

Pica might be caused by the parathyroid because it was induced in rats
http://www.ncbi.nlm.nih.gov/pubmed/?term=pica+parathyroid

Could Candida be infecting the parathyroid?

parathyroid is connected with autoimmune polyglandular syndrome one which is already associated with candida infections

Dermatomyositis and lichen planus?
http://www.ncbi.nlm.nih.gov/pubmed/25241001
http://www.ncbi.nlm.nih.gov/pubmed/25545122
http://www.ncbi.nlm.nih.gov/pubmed/4754227

Dermatomyositis and sjogren's
http://www.ncbi.nlm.nih.gov/pubmed/26253095

Vitiligo and polymyositis
http://www.ncbi.nlm.nih.gov/pubmed/24383911
http://www.ncbi.nlm.nih.gov/pubmed/2758715

Hashimoto's and polymyositis
http://www.kjim.org/upload/kjim-28-380.pdf

Leishmaniasis and dermatomyositis
http://www.ncbi.nlm.nih.gov/pubmed/8698915
http://www.thelancet.com/pdfs/journals/lancet/PIIS0140-6736(05)63428-9.pdf

acute autoimmmune optic neuritis after chickungunya infection
http://www.sciencedirect.com/science/article/pii/S1201971210025270

optic neuritis has been known to be triggered in dermatomyosis
http://rheumatology.oxfordjournals.org/content/43/3/391.2.long

Note that Leishmania parasite infects the sheath of the optic nerve
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3110707/

Macrophages are a major factor in polymyositis
http://www.ncbi.nlm.nih.gov/pubmed/15266639

 chikungunya usually infects macrophages
http://www.jci.org/articles/view/40104

So I guess the outer infection could be fungus or something like Leishmania. The inner infection a virus like coxsackie or chikungunya????







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